Palladium-mediated three-component synthesis of furo[2,3-b]pyridones by one-pot coupling of 3-lodopyridones, alkynes, and organic halides

被引：83

作者：

Bossharth, E

Desbordes, P

Monteiro, N

Balme, G

机构：

[1] Univ Lyon 1, CNRS, UMR 5622, Lab Chim Organ 1, F-69622 Villeurbanne, France

[2] Bayer CropSci, F-69623 Lyon, France

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 14期

关键词：

D O I：

10.1021/ol034644y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

graphic The one-pot assembly of 4-alkoxy-3-iodo-2-pyridones, terminal alkynes, and organic halides has been achieved by integration of two sequential palladium-mediated cross-coupling reactions-Sonogashira and Wacker-type heteroannulation processes-and subsequent deprotection of the alkoxy group to afford furo[2,3-b]pyridones.

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页码：2441 / 2444

页数：4

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