Negative regulation of receptor tyrosine kinase signals

被引：37

作者：

Fiorini, M

Alimandi, M

Fiorentino, L

Sala, G

Segatto, O

机构：

[1] Regina Elena Inst Canc Res, Immunol Lab, I-00158 Rome, Italy

[2] Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy

来源：

FEBS LETTERS | 2001年 / 490卷 / 03期

关键词：

receptor tyrosine kinase; signal inhibition; feedback inhibitor; negative signaling; cell cycle;

D O I：

10.1016/S0014-5793(01)02116-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In Metazoans a number of cellular functions are controlled by receptor tyrosine kinases (RTKs) during development and in postnatal life. The execution of these programs requires that signals of adequate strength are delivered for the appropriate time within precise spatial boundaries. Several RTK inhibitors have been identified in invertebrate and mammalian organisms. Because they are involved in tuning and termination of receptor signals, negative regulators of RTK activity fulfill a fundamental function in the control of receptor signaling, (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：132 / 141

页数：10

共 53 条

[41]

Pawson T, 2000, GENE DEV, V14, P1027

[42] There must be 50 ways to rule the signal: The case of the Drosophila EGF receptor [J].