Regioselective synthesis of substituted naphthalenes:: A novel de novo approach based on a metal-free protocol for stepwise cycloaddition of o-alkynylbenzaldehyde derivatives with either alkynes or alkenes

被引：134

作者：

Barluenga, J ^{[1
]}

Váquez-Villa, H ^{[1
]}

Ballesteros, A ^{[1
]}

González, JM ^{[1
]}

机构：

[1] Univ Oviedo, Inst Quim Organomet Enrique Moles, Unidad Asociada, CSIC, E-33006 Oviedo, Spain

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 22期

关键词：

D O I：

10.1021/ol035691t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHIC] Iodonium ions, o-alkynyl-substituted carbonyl compounds, and alkynes react to give 1-iodonaphthalene derivatives featuring interesting substitution patterns. The reaction with alkenes instead of acetylenes affords related naphthyl ketone derivatives. These two metal-free processes are conducted at room temperature and furnish products in a regioselective manner.

引用

页码：4121 / 4123

页数：3

共 20 条

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