Effect of water on the palladium-catalyzed amidation of aryl bromides

被引：47

作者：

Dallas, AS

Gothelf, KV

机构：

[1] Aarhus Univ, Dept Chem, Interdisciplinary Nanosci Ctr, DK-8000 Aarhus, Denmark

[2] Aarhus Univ, Dept Chem, Ctr Catalysis, DK-8000 Aarhus, Denmark

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 08期

关键词：

D O I：

10.1021/jo0500176

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The presence of water was found to have a significant impact on the conversion of some Hartwig-Buchwald reactions between amides with arylbromides. Seven amidation reactions were studied in a series of experiments containing 0-400 mol % water. When cesium carbonate is used as the base both in dioxane and toluene, water can have a beneficial effect. The experiments have also shown that for some reactions, anhydrous conditions are unnecessary and sometimes can hinder the reaction.

引用

页码：3321 / 3323

页数：3

共 31 条

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