NMDA receptor-mediated oscillatory activity in the neonatal rat spinal cord is serotonin dependent

被引：63

作者：

MacLean, JN ^{[1
]}

Cowley, KC ^{[1
]}

Schmidt, BJ ^{[1
]}

机构：

[1] Univ Manitoba, Dept Physiol, Winnipeg, MB R3E 0W3, Canada

来源：

JOURNAL OF NEUROPHYSIOLOGY | 1998年 / 79卷 / 05期

关键词：

D O I：

10.1152/jn.1998.79.5.2804

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of serotonin (5-HT) receptor blockade on rhythmic network activity and on N-methyl-D-aspartate (NMDA) receptor-induced membrane voltage oscillations was examined using an in vitro neonatal rat spinal cord preparation. Pharmacologically induced rhythmic hindlimb activity, monitored via flexor and extensor electroneurograms or ventral root recordings, was abolished by 5-HT receptor antagonists. Intrinsic motoneuronal voltage oscillations, induced by NMDA in the presence of tetrodotoxin (TTX), either were abolished completely or transformed to longlasting voltage shifts by 5-HT receptor antagonists. Conversely, 5-HT application facilitated the expression of NMDA-receptor-mediated rhythmic voltage oscillations. The results suggest that an interplay between 5-HT and NMDA receptor actions may be critical for the production of rhythmic motor behavior in the mammalian spinal cord, both at the network and single cell level.

引用

页码：2804 / 2808

页数：5

共 40 条

[1] MODIFICATION OF LUMBAR MOTONEURON EXCITABILITY BY STIMULATION OF A PUTATIVE 5-HYDROXYTRYPTAMINE PATHWAY [J].

BARASI, S ;

ROBERTS, MHT .

BRITISH JOURNAL OF PHARMACOLOGY, 1974, 52 (03) :339-348

[2] THE EFFECTS OF SEROTONERGIC DRUGS ON THE LOCOMOTOR PATTERN AND ON CUTANEOUS REFLEXES OF THE ADULT CHRONIC SPINAL CAT [J].

BARBEAU, H ;

ROSSIGNOL, S .

BRAIN RESEARCH, 1990, 514 (01) :55-67

[3] Contribution of NMDA and non-NMDA glutamate receptors to locomotor pattern generation in the neonatal rat spinal cord [J].

Beato, M ;

Bracci, E ;

Nistri, A .

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1997, 264 (1383) :877-884

[4]

Blank T, 1996, J NEUROSCI RES, V45, P153, DOI 10.1002/(SICI)1097-4547(19960715)45:2<153::AID-JNR7>3.0.CO

[5]

2-9

[6] ACTIVATION OF THE CENTRAL PATTERN GENERATORS FOR LOCOMOTION BY SEROTONIN AND EXCITATORY AMINO-ACIDS IN NEONATAL RAT [J].

CAZALETS, JR ;

SQALLIHOUSSAINI, Y ;

CLARAC, F .

JOURNAL OF PHYSIOLOGY-LONDON, 1992, 455 :187-204

[7] SEROTONIN DIFFERENTIALLY MODULATES RESPONSES MEDIATED BY SPECIFIC EXCITATORY AMINO-ACID RECEPTORS IN THE RAT LOCUS-CERULEUS [J].

CHARLETY, PJ ;

CHERGUI, K ;

AKAOKA, H ;

SAUNIER, CF ;

BUDA, M ;

ASTONJONES, G ;

CHOUVET, G .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1993, 5 (08) :1024-1028

[8] PROTEIN-KINASE-C REDUCES MG2+ BLOCK OF NMDA-RECEPTOR CHANNELS AS A MECHANISM OF MODULATION [J].

CHEN, L ;

HUANG, LYM .

NATURE, 1992, 356 (6369) :521-523

[9] Voltage-dependent block of NMDA responses by 5-HT agonists in ventral spinal cord neurones [J].

ChesnoyMarchais, D ;

Barthe, JY .

BRITISH JOURNAL OF PHARMACOLOGY, 1996, 117 (01) :133-141

[10] EFFECTS OF INHIBITORY AMINO-ACID ANTAGONISTS ON RECIPROCAL INHIBITORY INTERACTIONS DURING RHYTHMIC MOTOR-ACTIVITY IN THE IN-VITRO NEONATAL RAT SPINAL-CORD [J].

COWLEY, KC ;

SCHMIDT, BJ .

JOURNAL OF NEUROPHYSIOLOGY, 1995, 74 (03) :1109-1117

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