Facile and efficient total synthesis of (+)-Preussin

被引：46

作者：

Lee, KY ^{[1
]}

Kim, YH ^{[1
]}

Oh, CY ^{[1
]}

Ham, WH ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Coll Pharm, Suwon 440746, South Korea

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 25期

关键词：

D O I：

10.1021/ol000289p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective total synthesis of (+)-preussin, a potent antifungal agent, has been achieved, The key steps are a Pd(0)-catalyzed oxazoline forming reaction from L-phenylalanine, hydrogenolysis, and subsequent diastereoselective reductive cyclization of the intermediate aminoketone to pyrrolidine using Pearlman's catalyst.

引用

页码：4041 / 4042

页数：2

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