A novel stereoselective synthesis of enantiomerically pure antifungal agent, (+)-preussin

被引：54

作者：

Yoda, H

Yamazaki, H

Takabe, K

机构：

[1] Department of Molecular Science, Faculty of Engineering, Shizuoka University

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 02期

关键词：

D O I：

10.1016/0957-4166(96)00009-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An efficient and novel process is described for the asymmetric synthesis of (2S,3S,SR)-1-methyl-5-nonyl-2-(phenylmethyl)-3-pyrrolidinol, (+)-preussin employing reductive deoxygenation of a functionalized quaternary alpha-hydroxy N-Boc pyrrolidine obtained by stereocontrolled elaboration of tri-O-benzyl-beta-D-arabinofuranose. The synthetic strategy involves no separation of stereoisomers through the entire sequence.

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收藏

页码：373 / 374

页数：2

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