Regioselective palladium-catalyzed phenylation of ethyl 4-oxazolecarboxylate

被引：69

作者：

Hoarau, C

de Kerdaniel, ADF

Bracq, N

Grandclaudon, P

Couture, A

Marsais, F

机构：

[1] Univ Rouen, IRCOF, UMR 6014, CNRS,Lab Chim Organ Fine & Heterocycl, F-76131 Mont St Aignan, France

[2] INSA, F-76131 Mont St Aignan, France

[3] UST Lille 1, COM, UMR 8009, CNRS,Lab Chim Organ Phys, F-59655 Villeneuve Dascq, France

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 49期

关键词：

ethyl; 4-oxazolecarboxylate; aryloxazoles; direct coupling; palladium;

D O I：

10.1016/j.tetlet.2005.09.192

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The efficient and regioselective palladium-catalyzed C-2 arylation of ethyl 4-oxazolecarboxylate 1 with phenyliodide is described. The different parameters (solvent, base, ligand and catalyst) for the optimal conditions of this arylation process have been screened. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：8573 / 8577

页数：5

共 38 条

[1] One-step synthesis of 2-arylbenzothiazole ('BTA') and -benzoxazole precursors for in vivo imaging of β-amyloid plaques [J].