One-step synthesis of 2-arylbenzothiazole ('BTA') and -benzoxazole precursors for in vivo imaging of β-amyloid plaques

被引：150

作者：

Alagille, D

Baldwin, RM

Tamagnan, GD

机构：

[1] Yale Univ, New Haven, CT 06510 USA

[2] VA CT, HCS, Dept Psychiat, New Haven, CT 06510 USA

[3] Inst Neurodegenerat Disorders, New Haven, CT 06510 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 08期

基金：

美国国家卫生研究院;

关键词：

2-arylbenzothiazole; BTA; 2-arylbenzoxazole; amyloid plaques; palladium; direct coupling;

D O I：

10.1016/j.tetlet.2004.12.111

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the simple and efficient synthesis of 2-arylbenzothiazoles ('BTA') and 2-arylbenzoxazoles by direct coupling of benzothiazoles or benzoxazoles with aryl bromides. This method permits direct one-step access to precursors of radiolabeled BTA-1 and BTA-2 and their 6-rnethoxy analogues, used for in vivo imaging of beta-amyloid plaques with positron emission tomography (PET). (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：1349 / 1351

页数：3

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