The energetics of genome complexity

被引：821

作者：

Lane, Nick ^{[1
]}

Martin, William ^{[2
]}

机构：

[1] UCL, Dept Genet Evolut & Environm, London W1E 6BT, England

[2] Univ Dusseldorf, Inst Bot 3, D-40225 Dusseldorf, Germany

来源：

NATURE | 2010年 / 467卷 / 7318期

基金：

欧洲研究理事会;

关键词：

MITOCHONDRIAL GENE-EXPRESSION; EUKARYOTIC GENOMES; EVOLUTION; BACTERIA; ORIGIN; CELL; OXYGEN; DNA; COMPARTMENTALIZATION; CHROMOSOMES;

D O I：

10.1038/nature09486

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

All complex life is composed of eukaryotic (nucleated) cells. The eukaryotic cell arose from prokaryotes just once in four billion years, and otherwise prokaryotes show no tendency to evolve greater complexity. Why not? Prokaryotic genome size is constrained by bioenergetics. The endosymbiosis that gave rise to mitochondria restructured the distribution of DNA in relation to bioenergetic membranes, permitting a remarkable 200,000-fold expansion in the number of genes expressed. This vast leap in genomic capacity was strictly dependent on mitochondrial power, and prerequisite to eukaryote complexity: the key innovation en route to multicellular life.

引用

页码：929 / 934

页数：6

共 75 条

[31] Cell compartmentalisation in planctomycetes: novel types of structural organisation for the bacterial cell [J].

Lindsay, MR ;

Webb, RI ;

Strous, M ;

Jetten, MS ;

Butler, MK ;

Forde, RJ ;

Fuerst, JA .

ARCHIVES OF MICROBIOLOGY, 2001, 175 (06) :413-429

[32] Endocytosis-like protein uptake in the bacterium Gemmata obscuriglobus [J].

Lonhienne, Thierry G. A. ;

Sagulenko, Evgeny ;

Webb, Richard I. ;

Lee, Kuo-Chang ;

Franke, Josef ;

Devos, Damien P. ;

Nouwens, Amanda ;

Carrolla, Bernard J. ;

Fuerst, John A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (29) :12883-12888

[33] The origins of genome complexity [J].

Lynch, M ;

Conery, JS .

SCIENCE, 2003, 302 (5649) :1401-1404

[34] Energetics of the smallest: do bacteria breathe at the same rate as whales? [J].

Makarieva, AM ;

Gorshkov, VG ;

Li, BL .

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2005, 272 (1577) :2219-2224

[35] REASSESSMENT OF ROLES OF OXYGEN AND ULTRAVIOLET-LIGHT IN PRECAMBRIAN EVOLUTION [J].

MARGULIS, L ;

WALKER, JCG ;

RAMBLER, M .

NATURE, 1976, 264 (5587) :620-624

[36] Introns and the origin of nucleus-cytosol compartmentalization [J].

Martin, W ;

Koonin, EV .

NATURE, 2006, 440 (7080) :41-45

[37] The hydrogen hypothesis for the first eukaryote [J].

Martin, W ;

Müller, M .

NATURE, 1998, 392 (6671) :37-41

[38] Extreme polyploidy in a large bacterium [J].

Mendell, Jennifer E. ;

Clements, Kendall D. ;

Choat, J. Howard ;

Angert, Esther R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (18) :6730-6734

[39] Symbiosis as an adaptive process and source of phenotypic complexity [J].

Moran, Nancy A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 :8627-8633

[40] Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants [J].

Moreno-Loshuertos, Raquel ;

Acin-Perez, Rebeca ;

Fernandez-Silva, Patricio ;

Movilla, Nieves ;

Perez-Martos, Acisclo ;

de Cordoba, Santiago Rodriguez ;

Gallardo, M. Esther ;

Enriquez, Jose Antonio .

NATURE GENETICS, 2006, 38 (11) :1261-1268

← 1 2 3 4 5 6 7 8 →