Cytotoxic diterpenoids from Isodon enanderianus

被引：2

作者：

Xiang, W

Na, Z

Li, SH

Li, ML

Li, RT

Tian, QE

Sun, HD ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

[2] Kunming Med Coll, Yunnan Phatmacol Lab Nat Prod, Kunming, Peoples R China

来源：

PLANTA MEDICA | 2003年 / 69卷 / 11期

关键词：

Isodon enanderianus; Labiatae; diterpenoids; ent-kaurane; ent-abietane; enanderianins K-P; cytotoxicity;

D O I：

暂无

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new ent-kaurane diterpenoids, enanderianins K-O (1-5), and one new ent-abietane diterpenoid, enanderianin P (6), together with five known ent-kaurane diterpenoids, rabdocoetsin A (7), rabdocoetsin B (8), rabdocoetsin D (9), megathyrin A (10), megathyrin B (11) were isolated from the aerial parts of Isodon enanderianus. Their structures were determined by spectral means. Some diterpenoids were tested for their cytotoxicity against the human tumor K562 cells. Compounds 1, 2, 6, 8, 9 showed significant inhibitory activities against K562 cells with IC50 values ranging from 0.13 to 0.87 mug/mL.

引用

页码：1031 / 1035

页数：5

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