Two novel plasmid-mediated cefotaxime-hydrolyzing β-lactamases (CTX-M-5 and CTX-M-6) from Salmonella typhimurium

被引：54

作者：

Gazouli, M

Tzelepi, E

Markogiannakis, A

Legakis, NJ

Tzouvelekis, LS ^{[2
]}

机构：

[1] Univ Athens, Sch Med, Dept Microbiol, Lab Antimicrobial Agents, GR-11527 Athens, Greece

[2] Hellen Pasteur Inst, Dept Bacteriol, Athens 11521, Greece

来源：

FEMS MICROBIOLOGY LETTERS | 1998年 / 165卷 / 02期

关键词：

Salmonella typhimurium; beta-lactamase; cefotaxime; resistance;

D O I：

10.1016/S0378-1097(98)00290-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two novel plasmid-mediated beta-lactamases (CTX-M-5 and CTX-M-6) produced by Salmonella typhimurium clinical strains were characterized. The enzymes exhibited a pI of 8.4, hydrolyzed oxyimino-beta-lactams and were susceptible to mechanism-based p-lactamase inhibitors. The respective bin genes were cloned and sequenced. The deduced amino acid sequences showed a high degree of homology with those of the previously described plasmid class A CTX-M-type enzymes and appeared related to the chromosomal p-lactamases of Klebsiella oxytoca. (C) 1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：289 / 293

页数：5

共 17 条

[11] CLONING AND SEQUENCE OF THE GENE ENCODING A CEFOTAXIME-HYDROLYZING CLASS-A BETA-LACTAMASE ISOLATED FROM ESCHERICHIA-COLI [J].