A search for a mutation of the Aiolos phosphorylation domain in lymphocytes from patients with leukemia

被引：3

作者：

Antica, Mariastefania ^{[1
]}

Dubravcic, Klara ^{[2
]}

Weber, Igor ^{[1
]}

Rasic, Ljubica ^{[2
]}

Labar, Boris ^{[2
]}

Batinic, Drago ^{[2
]}

机构：

[1] Rudjer Boskovic Inst, Div Mol Biol, Zagreb, Croatia

[2] Rebro Clin Hosp, Zagreb, Croatia

来源：

HAEMATOLOGICA | 2007年 / 92卷 / 02期

关键词：

lymphocytes; leukemia; Aiolos;

D O I：

10.3324/haematol.10753

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We examined whether phosphorylation of Aiolos in primary human lymphocytes is part of the malignant transformation in leukemia. By analyzing mutations at a restriction site we show here that impairment of Aiolos activity in human leukemia is not based on deficient phosphorylation as had been demonstrated in experiments in vitro.

引用

页码：260 / 261

页数：2

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