Amine-modified single-walled carbon nanotubes protect neurons from injury in a rat stroke model

被引：191

作者：

Lee, Hyun Jung ^{[1
]}

Park, Jiae ^{[1
]}

Yoon, Ok Ja ^{[2
,3
]}

Kim, Hyun Woo ^{[2
,3
]}

Lee, Do Yeon ^{[1
]}

Kim, Do Hee ^{[1
]}

Lee, Won Bok ^{[1
]}

Lee, Nae-Eung ^{[2
,3
]}

Bonventre, Joseph V. ^{[4
]}

Kim, Sung Su ^{[1
]}

机构：

[1] Chung Ang Univ, Coll Med, Dept Anat & Cell Biol, Seoul 156756, South Korea

[2] Sungkyunkwan Univ, Sch Adv Mat Sci & Engn, SKKU Adv Inst Nanotechnol, Suwon 440746, Kyunggi Do, South Korea

[3] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Suwon 440746, Kyunggi Do, South Korea

[4] Harvard Univ, Sch Med, Dept Med, Div Renal, Boston, MA USA

来源：

NATURE NANOTECHNOLOGY | 2011年 / 6卷 / 02期

关键词：

N-CADHERIN; BRAIN; INFLAMMATION; CELLS;

D O I：

10.1038/nnano.2010.281

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Stroke results in the disruption of tissue architecture and is the third leading cause of death in the United States(1). Transplanting scaffolds containing stem cells into the injured areas of the brain has been proposed as a treatment strategy(2), and carbon nanotubes show promise in this regard, with positive outcomes when used as scaffolds in neural cells(3,4) and brain tissues(5). Here, we show that pretreating rats with amine-modified single-walled carbon nanotubes can protect neurons and enhance the recovery of behavioural functions in rats with induced stroke. Treated rats showed less tissue damage than controls and took longer to fall from a rotating rod, suggesting better motor functions after injury. Low levels of apoptotic, angiogenic and inflammation markers indicated that amine-modified single-walled carbon nanotubes protected the brains of treated rats from ischaemic injury.

引用

页码：120 / 124

页数：5

共 23 条

[1]

Cellot G, 2009, NAT NANOTECHNOL, V4, P126, DOI [10.1038/NNANO.2008.374, 10.1038/nnano.2008.374]

[2] Amino group introduction onto multiwall carbon nanotubes by NH3/Ar plasma treatment [J].