Type I interferon: friend or foe?

被引：671

作者：

Trinchieri, Giorgio ^{[1
]}

机构：

[1] NCI, Canc & Inflammat Program, Ctr Canc Res, NIH, Frederick, MD 21702 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2010年 / 207卷 / 10期

关键词：

PLASMACYTOID DENDRITIC CELLS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; VIRUS-TRANSFORMED CELLS; TOLL-LIKE RECEPTORS; DOUBLE-STRANDED-RNA; MYCOBACTERIUM-TUBERCULOSIS; LISTERIA-MONOCYTOGENES; IFN-ALPHA; RIG-I; CHLAMYDIA-TRACHOMATIS;

D O I：

10.1084/jem.20101664

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although the role of type I interferon (IFN) in the protection against viral infections has been known and studied for decades, its role in other immunologically relevant scenarios, including bacterial infections, shock, autoimmunity, and cancer, is less well defined and potentially much more complicated.

引用

页码：2053 / 2063

页数：11

共 114 条

[31] Interferon-α and cancer:: Mechanisms of action and new perspectives of clinical use [J].

Ferrantini, Maria ;

Capone, Imerio ;

Belardelli, Filippo .

BIOCHIMIE, 2007, 89 (6-7) :884-893

[32] Cutting edge:: A murine, IL-12-independent pathway of IFN-γ induction by gram-negative:: Bacteria based on STAT4 activation by type I IFN and IL-18 signaling [J].

Freudenberg, MA ;

Merlin, T ;

Kalis, C ;

Chvatchko, Y ;

Stübig, H ;

Galanos, C .

JOURNAL OF IMMUNOLOGY, 2002, 169 (04) :1665-1668

[33] Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8 [J].

Ganguly, Dipyaman ;

Chamilos, Georgios ;

Lande, Roberto ;

Gregorio, Josh ;

Meller, Stephan ;

Facchinetti, Valeria ;

Homey, Bernhard ;

Barrat, Franck J. ;

Zal, Tomasz ;

Gilliet, Michel .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (09) :1983-1994

[34] A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells [J].

Gautier, G ;

Humbert, M ;

Deauvieau, F ;

Scuiller, M ;

Hiscott, J ;

Bates, EEM ;

Trinchieri, G ;

Caux, C ;

Garrone, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (09) :1435-1446

[35] Exogenous gamma and alpha/beta interferon rescues human macrophages from cell death induced by Bacillus anthracis [J].

Gold, JA ;

Hoshino, Y ;

Hoshino, S ;

Jones, MB ;

Nolan, A ;

Weiden, MD .

INFECTION AND IMMUNITY, 2004, 72 (03) :1291-1297

[36] Double stranded RNA tricks melanoma cells into committing suicide [J].

Goldszmid, Romina S. ;

Hasan, Uzma A. ;

Trinchieri, Giorgio .

PIGMENT CELL & MELANOMA RESEARCH, 2009, 22 (06) :705-706

[37] Functional Crosstalk between Type I and II Interferon through the Regulated Expression of STAT1 [J].

Gough, Daniel J. ;

Messina, Nicole L. ;

Hii, Linda ;

Gould, Jodee A. ;

Sabapathy, Kanaga ;

Robertson, Ashley P. S. ;

Trapani, Joseph A. ;

Levy, David E. ;

Hertzog, Paul J. ;

Clarke, Christopher J. P. ;

Johnstone, Ricky W. .

PLOS BIOLOGY, 2010, 8 (04)

[38] Signalling pathways leading to IFN-α production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications [J].

Guiducci, C. ;

Coffman, R. L. ;

Barrat, F. J. .

JOURNAL OF INTERNAL MEDICINE, 2009, 265 (01) :43-57

[39] TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus [J].

Guiducci, Cristiana ;

Gong, Mei ;

Xu, Zhaohui ;

Gill, Michelle ;

Chaussabel, Damien ;

Meeker, Thea ;

Chan, Jean H. ;

Wright, Tracey ;

Punaro, Marilynn ;

Bolland, Silvia ;

Soumelis, Vassili ;

Banchereau, Jacques ;

Coffman, Robert L. ;

Pascual, Virginia ;

Barrat, Franck J. .

NATURE, 2010, 465 (7300) :937-U10

[40] The type IIFN induction pathway constrains Th17-mediated autoimmune inflammation in mice [J].

Guo, Beichu ;

Chang, Elmer Y. ;

Cheng, Genhong .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (05) :1680-1690

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