Type I interferon: friend or foe?

被引：671

作者：

Trinchieri, Giorgio ^{[1
]}

机构：

[1] NCI, Canc & Inflammat Program, Ctr Canc Res, NIH, Frederick, MD 21702 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2010年 / 207卷 / 10期

关键词：

PLASMACYTOID DENDRITIC CELLS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; VIRUS-TRANSFORMED CELLS; TOLL-LIKE RECEPTORS; DOUBLE-STRANDED-RNA; MYCOBACTERIUM-TUBERCULOSIS; LISTERIA-MONOCYTOGENES; IFN-ALPHA; RIG-I; CHLAMYDIA-TRACHOMATIS;

D O I：

10.1084/jem.20101664

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although the role of type I interferon (IFN) in the protection against viral infections has been known and studied for decades, its role in other immunologically relevant scenarios, including bacterial infections, shock, autoimmunity, and cancer, is less well defined and potentially much more complicated.

引用

页码：2053 / 2063

页数：11

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