DMSO-aided o-iodoxybenzoic acid (IBX) oxidation of Fmoc-protected amino alcohols

被引：9

作者：

Chen, Jack J. ^{[1
]}

Aduda, Vince ^{[1
]}

机构：

[1] Wyeth Res, Pearl River, NY 10965 USA

来源：

SYNTHETIC COMMUNICATIONS | 2007年 / 37卷 / 19-21期

关键词：

amino alcohol; amino aldehyde; periodinane oxidation;

D O I：

10.1080/00397910701555469

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A fast and highly convenient procedure for the formation of Fmoc-protected amino aldehydes from the corresponding alcohols using 1.1 equiv. of IBX in the presence of dimethylsulfoxide (DMSO) is discussed. This procedure leads to the clean synthesis of Fmoc-amino aldehydes in excellent yields with less than 1% epimerization and with no chromatography required for purification.

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页码：3493 / 3499

页数：7

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