The need for littermate controls

被引：58

作者：

Holmdahl, Rikard ^{[1
]}

Malissen, Bernard ^{[2
]}

机构：

[1] Karolinska Inst, Div Med Inflammat Res, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden

[2] Ctr Immunol Marseille Luminy, Marseille, France

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2012年 / 42卷 / 01期

关键词：

Animal models; Genetics; Transgenic models; MICE; AUTOIMMUNITY; ARTHRITIS; ENCEPHALOMYELITIS; DISEASE; CELLS; IL-21; GENE;

D O I：

10.1002/eji.201142048

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The dramatic increase in the amount of research data being produced necessarily leads to higher demands on statistical thresholds and on experimental planning. This is to avoid positive selection of multiple tested data. Here we would like to highlight the need for including littermate controls in animal experiments, in particular when genetically modified strains are analysed for quantitative phenotypes. Thus, this suggestion will have impact on most immunological experiments performed today.

引用

页码：45 / 47

页数：3

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