Central nervous system effects of leptin

被引：21

作者：

Buchanan, C ^{[1
]}

Mahesh, V ^{[1
]}

Zamorano, P ^{[1
]}

Brann, D ^{[1
]}

机构：

[1] Med Coll Georgia, Dept Physiol & Endocrinol, Augusta, GA 30912 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1998年 / 9卷 / 04期

关键词：

D O I：

10.1016/S1043-2760(98)00038-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Evidence exists demonstrating the importance of leptin in the control of energy homeostasis, feeding behavior and reproductive function. Leptin receptors are localized in several regions of the brain implicated in regulation of energy balance and reproductive function, including the arcuate nucleus/median eminence, paraventricular nucleus, and ventromedial nucleus. Administration of exogenous leptin has been shown to alter function of the hypothalamic-pituitary-adrenal axis and stimulate gonadotropin release through hypothalamic and pituitary actions. Results from in situ hybridization studies demonstrate the ability of leptin to modulate the expression of key neuropeptides (neuropeptide Y, corticotropin releasing hormone) implicated in the regulation of energy homeostasis. This suggests that leptin is an important component in the neuroendocrine transmission line that regulates appetite, energy balance and reproduction.

引用

页码：146 / 150

页数：5

共 45 条

[31] Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus [J].

Mercer, JG ;

Hoggard, N ;

Williams, LM ;

Lawrence, CB ;

Hannah, LT ;

Morgan, PJ ;

Trayhurn, P .

JOURNAL OF NEUROENDOCRINOLOGY, 1996, 8 (10) :733-735

[32] Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice [J].

Mercer, JG ;

Moar, KM ;

Rayner, DV ;

Trayhurn, P ;

Hoggard, N .

FEBS LETTERS, 1997, 402 (2-3) :185-188

[33] Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization [J].

Mercer, JG ;

Hoggard, N ;

Williams, LM ;

Lawrence, CB ;

Hannah, LT ;

Trayhurn, P .

FEBS LETTERS, 1996, 387 (2-3) :113-116

[34] PATTERN OF GONADOTROPIN-RELEASING-HORMONE (GNRH) SECRETION LEADING UP TO OVULATION IN THE EWE - EXISTENCE OF A PREOVULATORY GNRH SURGE [J].

MOENTER, SM ;

CARATY, A ;

LOCATELLI, A ;

KARSCH, FJ .

ENDOCRINOLOGY, 1991, 129 (03) :1175-1182

[35] EFFECTS OF THE OBESE GENE-PRODUCT ON BODY-WEIGHT REGULATION IN OB/OB MICE [J].

PELLEYMOUNTER, MA ;

CULLEN, MJ ;

BAKER, MB ;

HECHT, R ;

WINTERS, D ;

BOONE, T ;

COLLINS, F .

SCIENCE, 1995, 269 (5223) :540-543

[36] CENTRAL EFFECTS OF CRF ON METABOLISM AND ENERGY-BALANCE [J].

ROTHWELL, NJ .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1990, 14 (03) :263-271

[37] BROWN ADIPOSE-TISSUE AFTER VENTROMEDIAL HYPOTHALAMIC-LESIONS IN RATS [J].

SAITO, M ;

MINOKOSHI, Y ;

SHIMAZU, T .

AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 248 (01) :E20-E25

[38] Identification of targets of leptin action in rat hypothalamus [J].

Schwartz, MW ;

Seeley, RJ ;

Campfield, LA ;

Burn, P ;

Baskin, DG .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (05) :1101-1106

[39] Melanocortin receptors in leptin effects [J].

Seeley, RJ ;

Yagaloff, KA ;

Fisher, SL ;

Burn, P ;

Thiele, TE ;

vanDijk, G ;

Baskin, DG ;

Schwartz, MW .

NATURE, 1997, 390 (6658) :349-349

[40] Identification and expression cloning of a leptin receptor, OB-R [J].

Tartaglia, LA ;

Dembski, M ;

Weng, X ;

Deng, NH ;

Culpepper, J ;

Devos, R ;

Richards, GJ ;

Campfield, LA ;

Clark, FT ;

Deeds, J ;

Muir, C ;

Sanker, S ;

Moriarty, A ;

Moore, KJ ;

Smutko, JS ;

Mays, GG ;

Woolf, EA ;

Monroe, CA ;

Tepper, RI .

CELL, 1995, 83 (07) :1263-1271

← 1 2 3 4 5 →