Total syntheses of macrocyclic marine alkaloids, haliclamines A and B: A convenient and expeditious assembly of 3-substituted pyridine derivatives with different alkyl chains to the bispyridinium macrocycle

被引：24

作者：

Morimoto, Y ^{[1
]}

Yokoe, C ^{[1
]}

Kurihara, H ^{[1
]}

Kinoshita, T ^{[1
]}

机构：

[1] Osaka City Univ, Dept Chem, Grad Sch Sci, Osaka 5588585, Japan

来源：

TETRAHEDRON | 1998年 / 54卷 / 40期

关键词：

D O I：

10.1016/S0040-4020(98)00752-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total syntheses of haliclamines A (1) and B (2), macrocyclic marine alkaloids closely related to the key bisdihydropyridine intermediate 3 of the biogenetically unique manzamine family, have efficiently been achieved via stepwise controlled inter- and intramolecular N-alkylations of 3-alkylpyridine derivatives such as 40 and 41. The general synthetic methodology toward the bispyridinium macrocycle 44, a key biogenetic equivalent of the polycyclic marine alkaloids, has been proposed through the total syntheses. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：12197 / 12214

页数：18

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