Biotransformation of 5α-hydroxy-14-eudesm-11-en-3-one by Rhizopus nigricans, Cunninghamella elegans and Mucor plumbeus

被引：13

作者：

Alarcon, Julio ^{[1
]}

Aguila, Sergio

Cornejo, Fabiola

Alderete, Joel

机构：

[1] Univ Bio Bio, Fac Ciencias, Dpto Ciencias Basicas, Chillan, Chile

[2] Univ Concepcion, Fac Ciencias Quim, Dpto Quim Organ, Concepcion, Chile

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2007年 / 48卷 / 1-2期

关键词：

eudesmanes; sesquiterpenes; biotransfon nation; microbiological hydroxylation; CHEMICAL-MICROBIOLOGICAL SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; AGAROFURAN ANTIFEEDANTS; GLIOCLADIUM-ROSEUM; SESQUITERPENES; SEMISYNTHESIS; CRYPTOMERIDIOL; BIOCONVERSION; CELASTRACEAE; DERIVATIVES;

D O I：

10.1016/j.molcatb.2007.06.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

5 alpha-Hydroxy-14-eudesm-11-en-3-one (1) was metabolised by the filamentous fungi Rhizopus nigricans, Cunninghamella elegans and Mucor plumbeus to produce four metabolites. Regioselective hydroxylation at C-6 and C-11 were detected. These 1-hydroxylated compounds can be chemically transformed into alpha-agarofuran. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：23 / 27

页数：5

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