Macrophage migration inhibitory factor (MIF) - Its potential role in tumor growth and tumor-associated angiogenesis

被引:114
作者
Nishihira, J
Ishibashi, T
Fukushima, T
Sun, BL
Sato, Y
Todo, S
机构
[1] Hokkaido Univ, Grad Sch Med, Dept Mol Biochem, Kita Ku, Sapporo, Hokkaido 0608638, Japan
[2] Hokkaido Univ, Grad Sch Med, Dept Surg 1, Kita Ku, Sapporo, Hokkaido 0608638, Japan
来源
TISSUE REMODELING | 2003年 / 995卷
关键词
angiogenesis; cytokine; inflammation; tumor; wound repair;
D O I
10.1111/j.1749-6632.2003.tb03220.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Macrophage migration inhibitory factor (MIF) functions as a pluripotent cytokine involved in broad-spectrum pathophysiological events in association with inflammation and immune responses. Several reports, including ours, have suggested that MIF is also involved in tumorigenesis; however, its precise role has not been fully investigated. We examined the effectiveness of anti-MIF antibodies on tumor growth and tumor-associated angiogenesis using murine colon cancer cell line, colon 26. We observed a significant inhibition of growth of tumors embedded on the back of BALB/c mice by treatment with anti-MIF antibodies. Next, we implanted a Millipore chamber filled with colon cancer cells in the subcutaneous fascia of the flanks of mice and then treated them with anti-MIF antibodies. We found that angiogenesis was markedly suppressed within the region of the subcutaneous fascia that was in contact with the chamber. To further assess the role of MIF in tumorigenesis, we established MIF transgenic mice, which demonstrated that tumor growth and the associated angiogenesis were significantly enhanced in comparison with control mice.
引用
收藏
页码:171 / 182
页数:12
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