Hairpin mimics with phenanthroline- and bipyridine-derived linkers

被引：5

作者：

Bianke, Gapian ^{[1
]}

Haener, Robert ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2007年 / 26卷 / 8-9期

关键词：

oligonucleotide hairpins; phenanthroline; bipyridine; thermal denaturation;

D O I：

10.1080/15257770701508026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis and structural stabilities of modified oligonucleotide hairpins containing phenanthroline- and bipyridine-modified loops is reported. Phenanthroline (phen) and bipyridine (bipy) building blocks were synthesized, incorporated into DNA-oligonucleotides, and analyzed by thermal denaturation experiments. The so modified oligomers were found to form stable hairpin structures. Tm values were not affected by divalent transition metals.

引用

页码：949 / 952

页数：4

共 22 条

[1]

Batey RT, 1999, ANGEW CHEM INT EDIT, V38, P2327

[2] A metal-coordinating DNA hairpin mimic [J].

Bianké, G ;

Häner, R .

CHEMBIOCHEM, 2004, 5 (08) :1063-1068

[3] SYNTHESIS OF SOME 2,9-DISUBSTITUTED-1,10-PHENANTHROLINES [J].

CHANDLER, CJ ;

DEADY, LW ;

REISS, JA .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1981, 18 (03) :599-601

[4] Oxidative thymine dimer repair in the DNA helix [J].

Dandliker, PJ ;

Holmlin, RE ;

Barton, JK .

SCIENCE, 1997, 275 (5305) :1465-1468

[5] SEQUENCE-SPECIFIC CLEAVAGE OF SINGLE-STRANDED-DNA - OLIGODEOXYNUCLEOTIDE-EDTA.FE(II) [J].

DREYER, GB ;

DERVAN, PB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (04) :968-972

[6] Convenient method for the preparation of 2′-deoxyribosylurea by thymidine oxidation and NMR study of both anomers [J].

Dubey, I ;

Pratviel, G ;

Robert, A ;

Meunier, B .

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2001, 20 (08) :1463-1471

[7] CIRCULAR-DICHROISM STUDIES OF AN OLIGODEOXYRIBONUCLEOTIDE CONTAINING A HAIRPIN LOOP MADE OF A HEXAETHYLENE GLYCOL CHAIN - CONFORMATION AND STABILITY [J].

DURAND, M ;

CHEVRIE, K ;

CHASSIGNOL, M ;

THUONG, NT ;

MAURIZOT, JC .

NUCLEIC ACIDS RESEARCH, 1990, 18 (21) :6353-6359

[8] The sequence-specific cleavage of RNA by artificial chemical ribonucleases [J].

Haner, R ;

Hall, J .

ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, 1997, 7 (04) :423-430

[9] Enhanced cooperative binding of oligonucleotides to form DNA duplexes mediated by metal ion chelation [J].

Horsey, I ;

Krishnan-Ghosh, Y ;

Balasubramanian, S .

CHEMICAL COMMUNICATIONS, 2002, (17) :1950-1951

[10] Directing flux in glycan biosynthetic pathways with a small molecule switch [J].

Kohler, JJ ;

Czlapinski, JL ;

Laughlin, ST ;

Schelle, MW ;

de Graffenried, CL ;

Bertozzi, CR .

CHEMBIOCHEM, 2004, 5 (10) :1455-1458

← 1 2 3 →