共 69 条
Type I Interferon Production Induced by Streptococcus pyogenes-Derived Nucleic Acids Is Required for Host Protection
被引:110
作者:

Gratz, Nina
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Microbiol Immunobiol & Genet, Max F Perutz Labs, Vienna, Austria Univ Vienna, Dept Microbiol Immunobiol & Genet, Max F Perutz Labs, Vienna, Austria

Hartweger, Harald
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Microbiol Immunobiol & Genet, Max F Perutz Labs, Vienna, Austria Univ Vienna, Dept Microbiol Immunobiol & Genet, Max F Perutz Labs, Vienna, Austria

论文数: 引用数:
h-index:
机构:

Kratochvill, Franz
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Microbiol Immunobiol & Genet, Max F Perutz Labs, Vienna, Austria Univ Vienna, Dept Microbiol Immunobiol & Genet, Max F Perutz Labs, Vienna, Austria

论文数: 引用数:
h-index:
机构:

Sigel, Stefanie
论文数: 0 引用数: 0
h-index: 0
机构:
Med Univ Vienna, Austrian Acad Sci, Res Ctr Mol Med, CEMM, Vienna, Austria
Med Univ Vienna, Dept Internal Med 1, Div Infect Dis & Trop Med, Vienna, Austria Univ Vienna, Dept Microbiol Immunobiol & Genet, Max F Perutz Labs, Vienna, Austria

Drobits, Barbara
论文数: 0 引用数: 0
h-index: 0
机构:
Med Univ Vienna, Dept Internal Med 1, Inst Canc Res, Vienna, Austria Univ Vienna, Dept Microbiol Immunobiol & Genet, Max F Perutz Labs, Vienna, Austria

Li, Xiao-Dong
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA Univ Vienna, Dept Microbiol Immunobiol & Genet, Max F Perutz Labs, Vienna, Austria

Knapp, Sylvia
论文数: 0 引用数: 0
h-index: 0
机构:
Med Univ Vienna, Austrian Acad Sci, Res Ctr Mol Med, CEMM, Vienna, Austria
Med Univ Vienna, Dept Internal Med 1, Div Infect Dis & Trop Med, Vienna, Austria Univ Vienna, Dept Microbiol Immunobiol & Genet, Max F Perutz Labs, Vienna, Austria

Kovarik, Pavel
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Microbiol Immunobiol & Genet, Max F Perutz Labs, Vienna, Austria Univ Vienna, Dept Microbiol Immunobiol & Genet, Max F Perutz Labs, Vienna, Austria
机构:
[1] Univ Vienna, Dept Microbiol Immunobiol & Genet, Max F Perutz Labs, Vienna, Austria
[2] Med Univ Vienna, Austrian Acad Sci, Res Ctr Mol Med, CEMM, Vienna, Austria
[3] Med Univ Vienna, Dept Internal Med 1, Div Infect Dis & Trop Med, Vienna, Austria
[4] Med Univ Vienna, Dept Internal Med 1, Inst Canc Res, Vienna, Austria
[5] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA
基金:
奥地利科学基金会;
关键词:
GROUP-A STREPTOCOCCI;
CYTOSOLIC DNA;
MOLECULAR-BASIS;
INNATE;
RECOGNITION;
INDUCTION;
PHAGOCYTOSIS;
MACROPHAGES;
ACTIVATION;
RESISTANCE;
D O I:
10.1371/journal.ppat.1001345
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Streptococcus pyogenes is a Gram-positive human pathogen that is recognized by yet unknown pattern recognition receptors (PRRs). Engagement of these receptor molecules during infection with S. pyogenes, a largely extracellular bacterium with limited capacity for intracellular survival, causes innate immune cells to produce inflammatory mediators such as TNF, but also type I interferon (IFN). Here we show that signaling elicited by type I IFNs is required for successful defense of mice against lethal subcutaneous cellulitis caused by S. pyogenes. Type I IFN signaling was accompanied with reduced neutrophil recruitment to the site of infection. Mechanistic analysis revealed that macrophages and conventional dendritic cells (cDCs) employ different signaling pathways leading to IFN-beta production. Macrophages required IRF3, STING, TBK1 and partially MyD88, whereas in cDCs the IFN-beta production was fully dependent on IRF5 and MyD88. Furthermore, IFN-beta production by macrophages was dependent on the endosomal delivery of streptococcal DNA, while in cDCs streptococcal RNA was identified as the IFN-beta inducer. Despite a role of MyD88 in both cell types, the known IFN-inducing TLRs were individually not required for generation of the IFN-beta response. These results demonstrate that the innate immune system employs several strategies to efficiently recognize S. pyogenes, a pathogenic bacterium that succeeded in avoiding recognition by the standard arsenal of TLRs.
引用
收藏
页数:16
相关论文
共 69 条
[11]
Macrophages recognize streptococci through bacterial single-stranded RNA
[J].
Deshmukh, Sachin D.
;
Kremer, Bernhard
;
Freudenberg, Marina
;
Bauer, Stefan
;
Golenbock, Douglas T.
;
Henneke, Philipp
.
EMBO REPORTS,
2011, 12 (01)
:71-76

Deshmukh, Sachin D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Med Ctr, Ctr Chron Immunodeficiency, D-79106 Freiburg, Germany Univ Freiburg, Med Ctr, Ctr Chron Immunodeficiency, D-79106 Freiburg, Germany

Kremer, Bernhard
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Med Ctr, Ctr Chron Immunodeficiency, D-79106 Freiburg, Germany Univ Freiburg, Med Ctr, Ctr Chron Immunodeficiency, D-79106 Freiburg, Germany

Freudenberg, Marina
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Immunobiol, D-79108 Freiburg, Germany Univ Freiburg, Med Ctr, Ctr Chron Immunodeficiency, D-79106 Freiburg, Germany

Bauer, Stefan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Marburg, BMFZ, Inst Immunol, D-35043 Marburg, Germany Univ Freiburg, Med Ctr, Ctr Chron Immunodeficiency, D-79106 Freiburg, Germany

Golenbock, Douglas T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA 01605 USA Univ Freiburg, Med Ctr, Ctr Chron Immunodeficiency, D-79106 Freiburg, Germany

Henneke, Philipp
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Med Ctr, Ctr Chron Immunodeficiency, D-79106 Freiburg, Germany
Univ Freiburg, Med Ctr, Ctr Paediat & Adolescent Med, D-79106 Freiburg, Germany Univ Freiburg, Med Ctr, Ctr Chron Immunodeficiency, D-79106 Freiburg, Germany
[12]
Cytokine induction by Gram-positive bacteria
[J].
Draing, Christian
;
Sigel, Stefanie
;
Deininger, Susanne
;
Traub, Stephanie
;
Munke, Rebekka
;
Mayer, Christoph
;
Hareng, Lars
;
Hartung, Thomas
;
von Aulock, Sonja
;
Hermann, Corinna
.
IMMUNOBIOLOGY,
2008, 213 (3-4)
:285-296

Draing, Christian
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Konstanz, D-78457 Constance, Germany Univ Konstanz, D-78457 Constance, Germany

Sigel, Stefanie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Konstanz, D-78457 Constance, Germany Univ Konstanz, D-78457 Constance, Germany

Deininger, Susanne
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Konstanz, D-78457 Constance, Germany Univ Konstanz, D-78457 Constance, Germany

Traub, Stephanie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Konstanz, D-78457 Constance, Germany Univ Konstanz, D-78457 Constance, Germany

Munke, Rebekka
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Konstanz, D-78457 Constance, Germany Univ Konstanz, D-78457 Constance, Germany

论文数: 引用数:
h-index:
机构:

Hareng, Lars
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Konstanz, D-78457 Constance, Germany
JRC, European Ctr Validat Alternat Methods, I-21020 Ispra, Italy Univ Konstanz, D-78457 Constance, Germany

Hartung, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Konstanz, D-78457 Constance, Germany
JRC, European Ctr Validat Alternat Methods, I-21020 Ispra, Italy Univ Konstanz, D-78457 Constance, Germany

von Aulock, Sonja
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Konstanz, D-78457 Constance, Germany Univ Konstanz, D-78457 Constance, Germany

Hermann, Corinna
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Konstanz, D-78457 Constance, Germany Univ Konstanz, D-78457 Constance, Germany
[13]
The role of the MHC on resistance to group A streptococci in mice
[J].
Goldmann, O
;
Lengeling, A
;
Böse, J
;
Bloecker, H
;
Geffers, R
;
Chhatwal, GS
;
Medina, E
.
JOURNAL OF IMMUNOLOGY,
2005, 175 (06)
:3862-3872

Goldmann, O
论文数: 0 引用数: 0
h-index: 0
机构: German Res Ctr Biotechnol, Gesell Biotechnol Forsch GmbH, Dept Microbial Pathogenesis & Vaccine Res, Div Microbiol,Infect Immunol Grp, D-38124 Braunschweig, Germany

Lengeling, A
论文数: 0 引用数: 0
h-index: 0
机构: German Res Ctr Biotechnol, Gesell Biotechnol Forsch GmbH, Dept Microbial Pathogenesis & Vaccine Res, Div Microbiol,Infect Immunol Grp, D-38124 Braunschweig, Germany

Böse, J
论文数: 0 引用数: 0
h-index: 0
机构: German Res Ctr Biotechnol, Gesell Biotechnol Forsch GmbH, Dept Microbial Pathogenesis & Vaccine Res, Div Microbiol,Infect Immunol Grp, D-38124 Braunschweig, Germany

Bloecker, H
论文数: 0 引用数: 0
h-index: 0
机构: German Res Ctr Biotechnol, Gesell Biotechnol Forsch GmbH, Dept Microbial Pathogenesis & Vaccine Res, Div Microbiol,Infect Immunol Grp, D-38124 Braunschweig, Germany

Geffers, R
论文数: 0 引用数: 0
h-index: 0
机构: German Res Ctr Biotechnol, Gesell Biotechnol Forsch GmbH, Dept Microbial Pathogenesis & Vaccine Res, Div Microbiol,Infect Immunol Grp, D-38124 Braunschweig, Germany

Chhatwal, GS
论文数: 0 引用数: 0
h-index: 0
机构: German Res Ctr Biotechnol, Gesell Biotechnol Forsch GmbH, Dept Microbial Pathogenesis & Vaccine Res, Div Microbiol,Infect Immunol Grp, D-38124 Braunschweig, Germany

Medina, E
论文数: 0 引用数: 0
h-index: 0
机构: German Res Ctr Biotechnol, Gesell Biotechnol Forsch GmbH, Dept Microbial Pathogenesis & Vaccine Res, Div Microbiol,Infect Immunol Grp, D-38124 Braunschweig, Germany
[14]
Role of macrophages in host resistance to group A streptococci
[J].
Goldmann, O
;
Rohde, M
;
Chhatwal, GS
;
Medina, E
.
INFECTION AND IMMUNITY,
2004, 72 (05)
:2956-2963

Goldmann, O
论文数: 0 引用数: 0
h-index: 0
机构:
GBF German Res Ctr Biotechnol, Dept Microbial Pathogenesis & Vaccine Res, D-38124 Braunschweig, Germany GBF German Res Ctr Biotechnol, Dept Microbial Pathogenesis & Vaccine Res, D-38124 Braunschweig, Germany

Rohde, M
论文数: 0 引用数: 0
h-index: 0
机构:
GBF German Res Ctr Biotechnol, Dept Microbial Pathogenesis & Vaccine Res, D-38124 Braunschweig, Germany GBF German Res Ctr Biotechnol, Dept Microbial Pathogenesis & Vaccine Res, D-38124 Braunschweig, Germany

Chhatwal, GS
论文数: 0 引用数: 0
h-index: 0
机构:
GBF German Res Ctr Biotechnol, Dept Microbial Pathogenesis & Vaccine Res, D-38124 Braunschweig, Germany GBF German Res Ctr Biotechnol, Dept Microbial Pathogenesis & Vaccine Res, D-38124 Braunschweig, Germany

Medina, E
论文数: 0 引用数: 0
h-index: 0
机构:
GBF German Res Ctr Biotechnol, Dept Microbial Pathogenesis & Vaccine Res, D-38124 Braunschweig, Germany GBF German Res Ctr Biotechnol, Dept Microbial Pathogenesis & Vaccine Res, D-38124 Braunschweig, Germany
[15]
Group A streptococcus activates type I interferon production and MyD88-dependent signaling without involvement of TLR2, TLR4, and TLR9
[J].
Gratz, Nina
;
Siller, Maria
;
Schaljo, Barbara
;
Pirzada, Zaid A.
;
Gattermeier, Irene
;
Vojtek, Ivo
;
Kirschning, Carsten J.
;
Wagner, Hermann
;
Charpentier, Emmanuelle
;
Kovarik, Pavel
;
Akira, Shizuo
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2008, 283 (29)
:19879-19887

Gratz, Nina
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria

Siller, Maria
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria

Schaljo, Barbara
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria

Pirzada, Zaid A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria

Gattermeier, Irene
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria

Vojtek, Ivo
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria

Kirschning, Carsten J.
论文数: 0 引用数: 0
h-index: 0
机构:
Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, Germany Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria

Wagner, Hermann
论文数: 0 引用数: 0
h-index: 0
机构:
Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, Germany Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria

Charpentier, Emmanuelle
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria

Kovarik, Pavel
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria

Akira, Shizuo
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, Res Inst Microbial Dis, Dept Host Def, Suita, Osaka 5650871, Japan Univ Vienna, Dept Microbiol & Immunobiol, Max F Perutz Labs, A-1030 Vienna, Austria
[16]
Cytolysin-dependent evasion of lysosomal killing
[J].
Håkansson, A
;
Bentley, CC
;
Shakhnovic, EA
;
Wessels, MR
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2005, 102 (14)
:5192-5197

Håkansson, A
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA

论文数: 引用数:
h-index:
机构:

Shakhnovic, EA
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA

Wessels, MR
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA
[17]
Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF-κB Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor
[J].
Harder, Juergen
;
Franchi, Luigi
;
Munoz-Planillo, Raul
;
Park, Jong-Hwan
;
Reimer, Thornik
;
Nunez, Gabriel
.
JOURNAL OF IMMUNOLOGY,
2009, 183 (09)
:5823-5829

Harder, Juergen
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Franchi, Luigi
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Munoz-Planillo, Raul
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Park, Jong-Hwan
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Reimer, Thornik
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Nunez, Gabriel
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
[18]
Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways
[J].
Henneke, P
;
Takeuchi, O
;
Malley, R
;
Lien, E
;
Ingalls, RR
;
Freeman, MW
;
Mayadas, T
;
Nizet, V
;
Akira, S
;
Kasper, DL
;
Golenbock, DT
.
JOURNAL OF IMMUNOLOGY,
2002, 169 (07)
:3970-3977

Henneke, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

Takeuchi, O
论文数: 0 引用数: 0
h-index: 0
机构: Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

Malley, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

Lien, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

Ingalls, RR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

Freeman, MW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

Mayadas, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

Nizet, V
论文数: 0 引用数: 0
h-index: 0
机构: Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

Akira, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

Kasper, DL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

Golenbock, DT
论文数: 0 引用数: 0
h-index: 0
机构: Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA
[19]
Lipoproteins are critical TLR2 activating toxins in group B streptococcal sepsis
[J].
Henneke, Philipp
;
Dramsi, Shaynoor
;
Mancuso, Giuseppe
;
Chraibi, Kamila
;
Pellegrini, Elisabeth
;
Theilacker, Christian
;
Huebner, Johannes
;
Santos-Sierra, Sandra
;
Teti, Giuseppe
;
Golenbock, Douglas T.
;
Poyart, Claire
;
Trieu-Cuot, Patrick
.
JOURNAL OF IMMUNOLOGY,
2008, 180 (09)
:6149-6158

Henneke, Philipp
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Freiburg, Ctr Pediat & Adolescent Med, D-79106 Freiburg, Germany Univ Med Ctr Freiburg, Ctr Pediat & Adolescent Med, D-79106 Freiburg, Germany

Dramsi, Shaynoor
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Unite Biol Bacteries Pathogenes Gram Positif, CNRS, URA 2172, Paris, France Univ Med Ctr Freiburg, Ctr Pediat & Adolescent Med, D-79106 Freiburg, Germany

论文数: 引用数:
h-index:
机构:

Chraibi, Kamila
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Unite Biol Bacteries Pathogenes Gram Positif, CNRS, URA 2172, Paris, France
Univ Paris 05, CNRS, INSERM,U 567,Inst Cochin, UMR 810, F-75270 Paris, France Univ Med Ctr Freiburg, Ctr Pediat & Adolescent Med, D-79106 Freiburg, Germany

Pellegrini, Elisabeth
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Unite Biol Bacteries Pathogenes Gram Positif, CNRS, URA 2172, Paris, France Univ Med Ctr Freiburg, Ctr Pediat & Adolescent Med, D-79106 Freiburg, Germany

Theilacker, Christian
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Freiburg, Dept Med, D-79106 Freiburg, Germany Univ Med Ctr Freiburg, Ctr Pediat & Adolescent Med, D-79106 Freiburg, Germany

Huebner, Johannes
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Freiburg, Dept Med, D-79106 Freiburg, Germany Univ Med Ctr Freiburg, Ctr Pediat & Adolescent Med, D-79106 Freiburg, Germany

Santos-Sierra, Sandra
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Freiburg, Ctr Pediat & Adolescent Med, D-79106 Freiburg, Germany Univ Med Ctr Freiburg, Ctr Pediat & Adolescent Med, D-79106 Freiburg, Germany

论文数: 引用数:
h-index:
机构:

Golenbock, Douglas T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01655 USA Univ Med Ctr Freiburg, Ctr Pediat & Adolescent Med, D-79106 Freiburg, Germany

Poyart, Claire
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Unite Biol Bacteries Pathogenes Gram Positif, CNRS, URA 2172, Paris, France Univ Med Ctr Freiburg, Ctr Pediat & Adolescent Med, D-79106 Freiburg, Germany

Trieu-Cuot, Patrick
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Unite Biol Bacteries Pathogenes Gram Positif, CNRS, URA 2172, Paris, France Univ Med Ctr Freiburg, Ctr Pediat & Adolescent Med, D-79106 Freiburg, Germany
[20]
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
[J].
Ishikawa, Hiroki
;
Ma, Zhe
;
Barber, Glen N.
.
NATURE,
2009, 461 (7265)
:788-U40

Ishikawa, Hiroki
论文数: 0 引用数: 0
h-index: 0
机构: Univ Miami, Miller Sch Med, Dept Med, Miami, FL 33136 USA

Ma, Zhe
论文数: 0 引用数: 0
h-index: 0
机构: Univ Miami, Miller Sch Med, Dept Med, Miami, FL 33136 USA

Barber, Glen N.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Miami, Miller Sch Med, Dept Med, Miami, FL 33136 USA Univ Miami, Miller Sch Med, Dept Med, Miami, FL 33136 USA