Regions in Ebola virus VP24 that are important for nucleocapsid formation

被引：46

作者：

Noda, Takeshi ^{[1
]}

Halfmann, Peter

Sagara, Hiroshi

Kawaoka, Yoshihiro

机构：

[1] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA

[2] Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Tokyo 1088639, Japan

[3] Univ Tokyo, Med Proteom Lab, Tokyo, Japan

[4] Univ Tokyo, Inst Med Sci, Div Virol, Dept Microbiol & Immunol, Tokyo, Japan

[5] Japan Sci & Technol Agcy, Core Res Evolut Sci & Technol, Tokyo, Saitama, Japan

来源：

JOURNAL OF INFECTIOUS DISEASES | 2007年 / 196卷

关键词：

D O I：

10.1086/520596

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ebola virus (EBOV) VP24, together with nucleoprotein and VP35, is an essential component of viral RNA-protein complexes called "nucleocapsids." In this study, using a series of deletion mutants of VP24, we identified regions within VP24 that are important for the formation of nucleocapsid-like structures and determined that both termini of VP24 are essential for nucleocapsid formation. This finding advances our knowledge of both EBOV morphogenesis and the nature of VP24 molecules in nucleocapsid formation, which will be useful for the development of antiviral compounds.

引用

页码：S247 / S250

页数：4

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