Non-selective voltage-activated cation channel in the human red blood cell membrane

被引：56

作者：

Kaestner, L ^{[1
]}

Bollensdorff, C ^{[1
]}

Bernhardt, I ^{[1
]}

机构：

[1] Humboldt Univ, Inst Biol, Biophys Sect, D-10115 Berlin, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1999年 / 1417卷 / 01期

关键词：

cation channel; erythrocyte; patch clamp; residual transport; low ionic strength;

D O I：

10.1016/S0005-2736(98)00240-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using the patch-clamp technique, a non-selective voltage-activated Na+ and K+ channel in the human red blood cell membrane was found. The channel operates only at positive membrane potentials from about +30 mV (inside positive) onwards. For sodium and potassium ions, similar conductances of about 21 pS were determined. Together with the recently described K+(Na+)/H+ exchanger, this channel is responsible for the increase of residual K+ and Na+ fluxes across the human red blood cell membrane when the cells are suspended in low ionic strength medium. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：9 / 15

页数：7

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