Solvent-Free Reaction between Anthranilic Acids and Isocyanides: A Novel Approach for the Synthesis of 2-Unsubstituted 4(3H)-Quinazolinones

被引：16

作者：

Adib, Mehdi ^{[1
]}

Karimzadeh, Morteza ^{[1
]}

Mahdavi, Mohammad ^{[1
]}

Sheikhi, Ehsan ^{[1
]}

Mirzaei, Peiman ^{[2
]}

机构：

[1] Univ Tehran, Sch Chem, Univ Coll Sci, POB 14155-6455, Tehran, Iran

[2] Shahid Beheshti Univ, Dept Chem, Tehran, Iran

来源：

SYNLETT | 2011年 / 06期

关键词：

anthranilic acids; isocyanides; 2-unsubstituted 4(3H)-quinazolinones; solvent-free synthesis; cyclizations; heterocycles; CARBOXYLIC-ACIDS; ONE-POT; EFFICIENT SYNTHESIS; ISONITRILES; INHIBITORS; DERIVATIVES; QUINAZOLINE; KINASE;

D O I：

10.1055/s-0030-1259909

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

A novel synthesis of 2-unsubstituted 4(3H)-quinazolinones is described. Heating a mixture of an anthranilic acid and an isocyanide under solvent-free conditions afforded the title compounds in good to excellent yields.

引用

收藏

页码：834 / 836

页数：3

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