On-line chemiluminescence determination of mitoxantrone by capillary electrophoresis

被引：26

作者：

Han, Suqin ^{[1
]}

Wang, Huili ^{[1
]}

机构：

[1] Shanxi Normal Univ, Sch Chem & Mat Sci, Linfen 041004, Shanxi, Peoples R China

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2010年 / 878卷 / 28期

基金：

中国国家自然科学基金;

关键词：

Mitoxantrone; Capillary electrophoresis; Chemiluminescence; Human urine; Human plasma; FLOW-INJECTION ANALYSIS;

D O I：

10.1016/j.jchromb.2010.08.006

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel capillary electrophoresis (CE) with chemiluminescence (CL) detection method for the determination of mitoxantrone (MTX) has been developed, which based on the CL reaction of potassium ferricyanide with luminol in sodium hydroxide medium sensitized by MTX. Under optimum analytical conditions, MTX is determined over the range of 7.0 x 10(-8)-1.0 x 10(-6) M with a detection limit of 1.0 x 10(-8) M. The relative standard deviation (RSD) was 3.7%, 2.6% and 3.0% for 7.0 x 10(-8), 5.0 x 10(-7) and 1.0 x 10(-6) M MTX (n = 11), respectively. In laboratory-built CE-CL apparatus, the proposed method has been applied to determination of MIX in commercial drug and spiked in human urine and plasma with satisfactory results. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：2901 / 2904

页数：4

共 22 条

[1] HPLC analysis of mitoxantrone in mouse plasma and tissues: Application in a pharmacokinetic study [J].

An, Guohua ;

Morris, Marilyn E. .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2010, 51 (03) :750-753

[2] DIRECT DETERMINATION OF MITOXANTRONE IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY USING AN AUTOMATIC PRECOLUMN-SWITCHING SYSTEM AS SAMPLE CLEANUP PROCEDURE [J].

CATALIN, J ;

PELOUX, AF ;

COLOMA, F ;

PAYET, B ;

LACARELLE, B ;

CANO, JP ;

JUSTLANDI, S .

BIOMEDICAL CHROMATOGRAPHY, 1994, 8 (01) :37-41

[3] Applications of capillary electrophoresis in forensic analytical chemistry [J].

Cruces-Blanco, C. ;

Gamiz-Gracia, L. ;

Garcia-Campana, A. M. .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2007, 26 (03) :215-226

[4] Chemiluminescence as a diagnostic tool. A review [J].

Dodeigne, C ;

Thunus, L ;

Lejeune, R .

TALANTA, 2000, 51 (03) :415-439

[5]

FLAVELLSOPSAMOR.U, 1988, J Immunol Meth, V115, P179

[6]

FRANCISCO J, 1998, TRENDS ANAL CHEM, V31, P2010

[7] Polarographic determination of mitoxantrone in pharmaceutical preparations and biological media [J].

Golabi, SM ;

HassanZadeh, V .

TALANTA, 1996, 43 (03) :397-406

[8] The role of mitoxantrone in the treatment of indolent lymphomas [J].

Hagemeister, F ;

Cabanillas, F ;

Coleman, M ;

Gregory, SA ;

Zinzani, PL .

ONCOLOGIST, 2005, 10 (02) :150-159

[9] Flow-injection chemiluminescence determination of phentolamine based on its enhancing effect on the luminol-potassium ferricyanide system [J].

Huang, YM ;

Liu, WB .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2005, 38 (03) :537-542

[10] Improved liquid chromatographic method for mitoxantrone quantification in mouse plasma and tissues to study the pharmacokinetics of a liposome entrapped mitoxantrone formulation [J].

Johnson, JL ;

Ahmad, A ;

Khan, S ;

Wang, YF ;

Abu-Qare, AW ;

Ayoub, JE ;

Zhang, A ;

Ahmad, I .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2004, 799 (01) :149-155

← 1 2 3 →