Phosphorescent Nanoscale Coordination Polymers as Contrast Agents for Optical Imaging

被引：230

作者：

Liu, Demin ^{[1
]}

Huxford, Rachel C. ^{[1
]}

Lin, Wenbin ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 16期

关键词：

imaging agents; nanoparticles; optical imaging; organic-inorganic hybrid composites; METAL-ORGANIC FRAMEWORKS; IN-VIVO; SILICA NANOPARTICLES; DELIVERY; PLATFORM;

D O I：

10.1002/anie.201008277

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Seeing is believing: Phosphorescent nanoscale coordination polymers (NCPs) with unprecedentedly high dye loadings were coated with thin silica shells to tune the dye release kinetics (see picture). Further functionalization of the NCP/ silica particles with poly(ethylene glycol) (PEG) and PEG-anisamide enhanced their biocompatibility and targeting ability, allowing cancer-specific imaging of human lung cancer H460 cells. (Figure Presented) © 2011 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：3696 / 3700

页数：5

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