Formal stereoselective synthesis of (±)-akagerine

被引：18

作者：

Bennasar, ML ^{[1
]}

Vidal, B ^{[1
]}

Sufi, BA ^{[1
]}

Bosch, J ^{[1
]}

机构：

[1] Univ Barcelona, Fac Pharm, Organ Chem Lab, E-08028 Barcelona, Spain

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 23期

关键词：

D O I：

10.1039/a807868h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A stereoselective synthesis of pentacyclic dilactam 1, a known precursor of the indole alkaloid akagerine, involving addition of the enolate of 1-acetylindole 2 to 3-acetyl-2-fluoropyridinium salt 3, cyclization of the resultant IP-dihydropyridine, elaboration of the (E)-ethylidene substituent and closure of the C ring by Pummerer reaction, is reported.

引用

页码：2639 / 2640

页数：2

共 12 条

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[7] FIRST ENANTIOSELECTIVE SYNTHESIS OF (-)-AKAGERINE BY A CHEMOENZYMATIC APPROACH
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[J]. JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (08) : 2506 - 2513
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[10] MASSIOT G, 1988, ALKALOIDS, V34, P211

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