Interrogating mouse mammary cancer models: Insights from gene expression profiling

被引：7

作者：

Fargiano, AA ^{[1
]}

Desai, KV ^{[1
]}

Green, JE ^{[1
]}

机构：

[1] NCI, TRansgen Oncogenesis Grp, Lab Cell Regulat & Carcinogenesis, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2003年 / 8卷 / 03期

关键词：

transgenic mouse models; breast cancer; gene expression profiling; oncogenic signaling pathways; microarrays; oncogenes;

D O I：

10.1023/B:JOMG.0000010032.05234.6f

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Numerous mouse models for mammary cancer have been developed and characterized based upon their biological, molecular, and histopathological features. In an effort to dissect the molecular anatomy of such models and compare their gene expression profiles to those of human breast cancer, six models representing various oncogenic pathways have been investigated using cDNA microarray technology. Results of these analyses are presented and discussed in the context of technological challenges presented by analyzing data on such a large scale. Further expression profiling coupled with emerging proteomic technologies will more completely define and distinguish mouse models of mammary cancer from each other and provide a comprehensive basis for comparing such models with the human disease they are intended to represent.

引用

页码：321 / 334

页数：14

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