Synthetic studies on thiostrepton: Construction of thiostrepton analogues with the thiazoline-containing macrocycle

被引：52

作者：

Nicolaou, KC

Nevalainen, M

Zak, M

Bulat, S

Bella, M

Safina, BS

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 29期

关键词：

amino acids; antibiotics; macrocycles; natural products; thiazolines;

D O I：

10.1002/anie.200351745

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Leading the way: The novel thiostrepton analogue 1 and its 5S, 6S diastereomer were synthesized through macrolactamization reactions. Forays towards the total synthesis of the natural product itself should follow a similar strategy.

引用

页码：3418 / 3424

页数：7

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