Plant-based vaccines

被引:123
作者
Streatfield, SJ [1 ]
Howard, JA [1 ]
机构
[1] ProdiGene Inc, College Stn, TX 77845 USA
关键词
plant expression; plant virus; protective immunity; subunit vaccine; transgenic plant; vaccine production;
D O I
10.1016/S0020-7519(03)00052-3
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Plant systems are reviewed with regard to their ability to express and produce subunit vaccines. Examples of different types of expression producing a variety of vaccine candidates are illustrated. Many of these subunit vaccines have been purified and shown to elicit an immune response when injected into animal models. This review also includes vaccines that have been administered orally in a non-purified form as a food or feed product. Cases are highlighted which demonstrate that orally delivered plant-based vaccines can elicit immune responses and in some case studies, confer protection. Examples are used to illustrate some of the inherent advantages of a plant-based system. such as cost, ease of scale-up and convenience of delivery. Also, some of the key steps are identified that will be necessary to bring these new vaccines to the market. (C) 2003 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:479 / 493
页数:15
相关论文
共 104 条
  • [61] Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice
    Mason, HS
    Ball, JM
    Shi, JJ
    Jiang, X
    Estes, MK
    Arntzen, CJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (11) : 5335 - 5340
  • [62] Production of immunogenic VP6 protein of bovine group A rotavirus in transgenic potato plants
    Matsumura, T
    Itchoda, N
    Tsunemitsu, H
    [J]. ARCHIVES OF VIROLOGY, 2002, 147 (06) : 1263 - 1270
  • [63] Rapid production of specific vaccines for lymphoma by expression of the tumor-derived single-chain Fv epitopes in tobacco plants
    McCormick, AA
    Kumagai, MH
    Hanley, K
    Turpen, TH
    Hakim, I
    Grill, LK
    Tusé, D
    Levy, S
    Levy, R
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (02) : 703 - 708
  • [64] EXPRESSION OF THE RABIES VIRUS GLYCOPROTEIN IN TRANSGENIC TOMATOES
    MCGARVEY, PB
    HAMMOND, J
    DIENELT, MM
    HOOPER, DC
    FU, ZF
    DIETZSCHOLD, B
    KOPROWSKI, H
    MICHAELS, FH
    [J]. BIO-TECHNOLOGY, 1995, 13 (13): : 1484 - 1487
  • [65] Analysis of the ability of five adjuvants to enhance immune responses to a chimeric plant virus displaying an HIV-1 peptide
    McInerney, TL
    Brennan, FR
    Jones, TD
    Dimmock, NJ
    [J]. VACCINE, 1999, 17 (11-12) : 1359 - 1368
  • [66] Stimulation of neutralizing antibodies to human immunodeficiency virus type 1 in three strains of mice immunized with a 22 amino acid peptide of gp41 expressed on the surface of a plant virus
    McLain, L
    Durrani, Z
    Wisniewski, LA
    Porta, C
    Lomonossoff, GP
    Dimmock, NJ
    [J]. VACCINE, 1996, 14 (08) : 799 - 810
  • [67] Immunization against rabies with plant-derived antigen
    Modelska, A
    Dietzschold, B
    Sleysh, N
    Fu, ZF
    Steplewski, K
    Hooper, DC
    Koprowski, H
    Yusibov, V
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) : 2481 - 2485
  • [68] Development of a plant-derived subunit vaccine candidate against hepatitis C virus
    Nemchinov, LG
    Liang, TJ
    Rifaat, MM
    Mazyad, HM
    Hadidi, A
    Keith, JM
    [J]. ARCHIVES OF VIROLOGY, 2000, 145 (12) : 2557 - 2573
  • [69] Characterization of the immune response to canine parvovirus induced by vaccination with chimaeric plant viruses
    Nicholas, BL
    Brennan, FR
    Martinez-Torrecuadrada, JL
    Casale, JI
    Hamilton, WD
    Wakelin, D
    [J]. VACCINE, 2002, 20 (21-22) : 2727 - 2734
  • [70] Rotavirus VP6 expressed by PVX vectors in Nicotiana benthamiana coats PVX rods and also assembles into viruslike particles
    O'Brien, GJ
    Bryant, CJ
    Voogd, C
    Greenberg, HB
    Gardner, RC
    Bellamy, AR
    [J]. VIROLOGY, 2000, 270 (02) : 444 - 453