Silk-based delivery systems of bioactive molecules

被引：296

作者：

Numata, Keiji ^{[1
]}

Kaplan, David L. ^{[1
]}

机构：

[1] Tufts Univ, Dept Biomed Engn, Medford, MA 02155 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2010年 / 62卷 / 15期

基金：

日本学术振兴会; 美国国家科学基金会;

关键词：

Silk; Recombinant protein; Gene delivery; Drug delivery; Biomaterials; Bioengineering; CELL-PENETRATING PEPTIDES; SPIDER DRAGLINE SILK; GENETICALLY-ENGINEERED SILK; MEDIATED GENE DELIVERY; BOMBYX-MORI SILK; IN-VITRO; CONTROLLED-RELEASE; NUCLEIC-ACIDS; BIOMATERIAL COATINGS; ADENOSINE RELEASE;

D O I：

10.1016/j.addr.2010.03.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Silks are biodegradable, biocompatible, self-assembling proteins that can also be tailored via genetic engineering to contain specific chemical features, offering utility for drug and gene delivery. Silkworm silk has been used in biomedical sutures for decades and has recently achieved Food and Drug Administration approval for expanded biomaterials device utility. With the diversity and control of size, structure and chemistry, modified or recombinant silk proteins can be designed and utilized in various biomedical application, such as for the delivery of bioactive molecules. This review focuses on the biosynthesis and applications of silk-based multi-block copolymer systems and related silk protein drug delivery systems. The utility of these systems for the delivery of small molecule drugs, proteins and genes is reviewed. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1497 / 1508

页数：12

共 145 条

[41] Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics [J].