Physiological responses to lysophosphatidic acid and related glycero-phospholipids

被引：84

作者：

Tigyi, G ^{[1
]}

机构：

[1] Univ Tennessee, Ctr Hlth Sci, Dept Physiol, Memphis, TN 38163 USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2001年 / 64卷 / 1-4期

关键词：

LPA; lipid mediator; phospholipid growth factor; lysolipid;

D O I：

10.1016/S0090-6980(01)00107-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1-Acyl-2-hydroxy(lyso)-sn-glycero-3-phosphate (lysophosphatidic acid, LPA) has attracted a lot of attention in recent years due to the wide range of its biological effects that span the phylogenetic tree from slime mold to human. LPA can he viewed as a pleiotropic phospholipid growth factor that utilizes the same signal transduction mechanisms as traditional polypeptide growth factors; however, LPA activates these mechanism via specific G protein-coupled receptors. The concentration of LPA in serum is in the high micromolar range, making it the most abundant mitogen/survival factor present in serum, one that is often unknowingly utilized in tissue culture. The present review fives a historical perspective and a critical analysis of the LPA literature with a special emphasis on the physiological implications of its effects. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：47 / 62

页数：16

共 115 条

[31]

HOWE LR, 1993, J BIOL CHEM, V268, P20717

[32] Albumin is a major serum survival factor for renal tubular cells and macrophages through scavenging of ROS [J].