β-D-Glucan kinetics for the assessment of treatment response in Pneumocystis jirovecii pneumonia

被引：36

作者：

Held, J. ^{[1
]}

Wagner, D. ^{[2
,3
]}

机构：

[1] Univ Freiburg, Inst Med Microbiol & Hyg, D-79104 Freiburg, Germany

[2] Univ Freiburg, Ctr Infect Dis & Travel Med, D-79104 Freiburg, Germany

[3] Univ Freiburg, Ctr Chron Immunodeficiency, D-79104 Freiburg, Germany

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2011年 / 17卷 / 07期

关键词：

beta-D-Glucan; follow-up; kinetic; Pneumocystis jirovecii pneumonia; therapy success; INVASIVE FUNGAL-INFECTIONS; EARLY-DIAGNOSIS;

D O I：

10.1111/j.1469-0691.2010.03452.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Serum (1 -> 3)-beta-D-Glucan (BG) is a biomarker for Pneumocystis jirovecii pneumonia (PJP). However, information concerning its usefulness for monitoring the clinical course is lacking. We conducted a retrospective study to investigate whether consecutive BG-measurements can be used to assess treatment response in PJP. Analysis of sera from 18 patients during PJP therapy shows that decreasing BG-levels strongly correlate with a favourable clinical course. In contrast, increasing BG-levels were associated with treatment failure or fatal outcome is only 44% of patients. As a consequence, BG-kinetics might be used to confirm treatment success but seem to be of limited value for the identification of treatment failure.

引用

页码：1118 / 1122

页数：6

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