Asymmetric transfer hydrogenation of ketones with bifunctional transition metal-based molecular
被引:1040
作者:
Ikariya, Takao
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Inst Technol, Grad Sch Sci, Dept Appl Chem, Tokyo 1528552, JapanTokyo Inst Technol, Grad Sch Sci, Dept Appl Chem, Tokyo 1528552, Japan
Ikariya, Takao
[1
]
Blacker, A. John
论文数: 0引用数: 0
h-index: 0
机构:
NPIL Pharma, Huddersfield HD1 9GA, W Yorkshire, England
Univ Leeds, Inst Proc Res & Dev, Leeds LS2 9JT, W Yorkshire, EnglandTokyo Inst Technol, Grad Sch Sci, Dept Appl Chem, Tokyo 1528552, Japan
Blacker, A. John
[2
,3
]
机构:
[1] Tokyo Inst Technol, Grad Sch Sci, Dept Appl Chem, Tokyo 1528552, Japan
[2] NPIL Pharma, Huddersfield HD1 9GA, W Yorkshire, England
[3] Univ Leeds, Inst Proc Res & Dev, Leeds LS2 9JT, W Yorkshire, England
Recent development of conceptually new chiral bifunctional transition metal based catalysts for asymmetric reductive transformations is described. The chiral bifunctional molecular catalyst promoted reduction is now realized to be a powerful tool to access chiral compounds in organic synthetic procedures in both academia and industry. Based on structural investigation of the actual catalyst and its intermediates and a deep understanding of the reaction mechanism, this asymmetric reduction system can be widely used to produce valuable chiral alcohols ani is now is applicable to commercial scale production.