Asymmetric transfer hydrogenation of ketones with bifunctional transition metal-based molecular

被引：1040

作者：

Ikariya, Takao ^{[1
]}

Blacker, A. John ^{[2
,3
]}

机构：

[1] Tokyo Inst Technol, Grad Sch Sci, Dept Appl Chem, Tokyo 1528552, Japan

[2] NPIL Pharma, Huddersfield HD1 9GA, W Yorkshire, England

[3] Univ Leeds, Inst Proc Res & Dev, Leeds LS2 9JT, W Yorkshire, England

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2007年 / 40卷 / 12期

关键词：

D O I：

10.1021/ar700134q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recent development of conceptually new chiral bifunctional transition metal based catalysts for asymmetric reductive transformations is described. The chiral bifunctional molecular catalyst promoted reduction is now realized to be a powerful tool to access chiral compounds in organic synthetic procedures in both academia and industry. Based on structural investigation of the actual catalyst and its intermediates and a deep understanding of the reaction mechanism, this asymmetric reduction system can be widely used to produce valuable chiral alcohols ani is now is applicable to commercial scale production.

引用

页码：1300 / 1308

页数：9

共 76 条

[1] Mechanism of the hydrogenation of ketones catalyzed by trans-dihydrido(diamine)ruthenium(II) complexes
Abdur-Rashid, K
Clapham, SE
Hadzovic, A
Harvey, JN
Lough, AJ
Morris, RH
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (50) : 15104 - 15118
[2] AKIYAMA S, 2005, 55 S COORD CHEM JAP, P88
[3] Ru(arene)(amino alcohol)-catalyzed transfer hydrogenation of ketones: Mechanism and origin of enantioselectivity
Alonso, DA
Brandt, P
Nordin, SJM
Andersson, PG
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (41) : 9580 - 9588
[4] 2-azanorbornyl alcohols: Very efficient ligands for ruthenium-catalyzed asymmetric transfer hydrogenation of aromatic ketones
Alonso, DA
Nordin, SJM
Roth, P
Tarnai, T
Andersson, PG
Thommen, M
Pittelkow, U
[J]. JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (10) : 3116 - 3122
[5] Synthesis and evaluation of a chiral heterogeneous transfer hydrogenation catalyst
Bayston, DJ
Travers, CB
Polywka, MEC
[J]. TETRAHEDRON-ASYMMETRY, 1998, 9 (12) : 2015 - 2018
[6] Blacker A. J., [No title captured], Patent No. [WO9842643B1, 9842643]
[7] Blacker A. J., 2007, Handbook of Homogeneous Hydrogenation, P1215
[8] BLACKER AJ, 2004, Patent No. 110976
[9] (CYCLOPENTADIENONE)RUTHENIUM CARBONYL-COMPLEXES - A NEW CLASS OF HOMOGENEOUS HYDROGENATION CATALYSTS
BLUM, Y
CZARKIE, D
RAHAMIM, Y
SHVO, Y
[J]. ORGANOMETALLICS, 1985, 4 (08) : 1459 - 1461
[10] Synthesis of water-soluble aminosulfonamide ligands and their application in enantioselective transfer hydrogenation
Bubert, C
Blacker, J
Brown, SM
Crosby, J
Fitzjohn, S
Muxworthy, JP
Thorpe, T
Williams, JMJ
[J]. TETRAHEDRON LETTERS, 2001, 42 (24) : 4037 - 4039

← 1 2 3 4 5 6 7 8 →