Asymmetric transfer hydrogenation of ketones with bifunctional transition metal-based molecular

被引:1040
作者
Ikariya, Takao [1 ]
Blacker, A. John [2 ,3 ]
机构
[1] Tokyo Inst Technol, Grad Sch Sci, Dept Appl Chem, Tokyo 1528552, Japan
[2] NPIL Pharma, Huddersfield HD1 9GA, W Yorkshire, England
[3] Univ Leeds, Inst Proc Res & Dev, Leeds LS2 9JT, W Yorkshire, England
关键词
D O I
10.1021/ar700134q
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Recent development of conceptually new chiral bifunctional transition metal based catalysts for asymmetric reductive transformations is described. The chiral bifunctional molecular catalyst promoted reduction is now realized to be a powerful tool to access chiral compounds in organic synthetic procedures in both academia and industry. Based on structural investigation of the actual catalyst and its intermediates and a deep understanding of the reaction mechanism, this asymmetric reduction system can be widely used to produce valuable chiral alcohols ani is now is applicable to commercial scale production.
引用
收藏
页码:1300 / 1308
页数:9
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