Asymmetric transfer hydrogenation of ketones with bifunctional transition metal-based molecular

被引:1040
作者
Ikariya, Takao [1 ]
Blacker, A. John [2 ,3 ]
机构
[1] Tokyo Inst Technol, Grad Sch Sci, Dept Appl Chem, Tokyo 1528552, Japan
[2] NPIL Pharma, Huddersfield HD1 9GA, W Yorkshire, England
[3] Univ Leeds, Inst Proc Res & Dev, Leeds LS2 9JT, W Yorkshire, England
关键词
D O I
10.1021/ar700134q
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Recent development of conceptually new chiral bifunctional transition metal based catalysts for asymmetric reductive transformations is described. The chiral bifunctional molecular catalyst promoted reduction is now realized to be a powerful tool to access chiral compounds in organic synthetic procedures in both academia and industry. Based on structural investigation of the actual catalyst and its intermediates and a deep understanding of the reaction mechanism, this asymmetric reduction system can be widely used to produce valuable chiral alcohols ani is now is applicable to commercial scale production.
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页码:1300 / 1308
页数:9
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