The SPFH domain-containing proteins: more than lipid raft markers

被引:296
作者
Browman, Duncan T. [1 ]
Hoegg, Maja B.
Robbins, Stephen M.
机构
[1] Univ Calgary, So Alberta Canc Res Inst, Dept Oncol & Biochem Mol Biol, Calgary, AB T2N 4N1, Canada
[2] Inst Pasteur, Unit Trafic Membranaire Pathogenese, F-75724 Paris, France
基金
加拿大健康研究院;
关键词
D O I
10.1016/j.tcb.2007.06.005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Membrane microdomains with distinct lipid compositions, called lipid rafts, represent a potential mechanism for compartmentalizing cellular functions within the plane of biological membranes. SPFH domain-containing proteins are found in lipid raft microdomains in diverse cellular membranes. The functions of these proteins are just beginning to be elucidated. Recent advances in the understanding of structural features and their roles within lipid rafts include a potential function for SPFH proteins in the formation of membrane microdomains and lipid raft-associated processes, such as endocytosis and mechanosensation.
引用
收藏
页码:394 / 402
页数:9
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