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Molecular epidemiology of extraintestinal pathogenic (uropathogenic) Escherichia coli
被引:191
作者:
Johnson, JR
Russo, TA
机构:
[1] Vet Adm Med Ctr, Mucosal & Vaccine Res Ctr, Minneapolis, MN 55417 USA
[2] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA
[3] Univ Buffalo, VA Med Ctr, Buffalo, NY USA
[4] Univ Buffalo, Dept Med, Buffalo, NY USA
[5] Univ Buffalo, Dept Microbiol, Buffalo, NY USA
[6] Univ Buffalo, Witebsky Ctr Microbial Pathogenesis & Immunol, Buffalo, NY USA
关键词:
Escherichia coli;
virulence factors;
phylogenetics;
urinary tract infection;
antimicrobial resistance;
pathogenicity;
molecular epidemiology;
D O I:
10.1016/j.ijmm.2005.07.005
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Molecular epidemiological analyses of extraintestinal pathogenic Escherichia coli (ExPEC), which are also called "uropathogenic E. coli" since they are the principle pathogens in urinary tract infection, involve structured observations of E. coli as they occur in the wild. Careful selection of subjects and use of appropriate methods for genotyping and statistical analysis are required for optimal results. Molecular epidemiological studies have helped to clarify the host-pathogen relationships, phylogenctic background, reservoirs, and transmission pathways of ExPEC, to assess potential vaccine candidates, and to delineate areas for further study. Ongoing discovery of new putative virulence factors (VFs), increasing awareness of the importance of VF expression and molecular variants of VFs, and growing appreciation of transmission as an important contributor to ExPEC infections provide abundant stimulus for future molecular epidemiological studies. Published by Elsevier GmbH.
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页码:383 / 404
页数:22
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