Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases

被引：147

作者：

Amarasekara, Dulshara Sachini ^{[1
]}

Yu, Jiyeon ^{[1
]}

Rho, Jaerang ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Biol Sci & Biotechnol, Dept Biosci & Biotechnol, Taejon 305764, South Korea

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2015年 / 2015卷

关键词：

NECROSIS-FACTOR-ALPHA; SYSTEMIC-LUPUS-ERYTHEMATOSUS; NF-KAPPA-B; COLLAGEN-INDUCED ARTHRITIS; STRUCTURAL JOINT DAMAGE; MESENCHYMAL STEM-CELLS; GROWTH-FACTOR-BETA; RHEUMATOID-ARTHRITIS; TNF-ALPHA; OSTEOBLAST DIFFERENTIATION;

D O I：

10.1155/2015/832127

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Bone remodeling is a lifelong process in vertebrates that relies on the correct balance between bone resorption by osteoclasts and bone formation by osteoblasts. Bone loss and fracture risk are implicated in inflammatory autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, and systemic lupus erythematosus. The network of inflammatory cytokines produced during chronic inflammation induces an uncoupling of bone formation and resorption, resulting in significant bone loss in patients with inflammatory autoimmune diseases. Here, we review and discuss the involvement of the inflammatory cytokine network in the pathophysiological aspects and the therapeutic advances in inflammatory autoimmune diseases.

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页数：12

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