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Mitotic checkpoints: from yeast to cancer

被引：177
作者：
Wassmann, K
Benezra, R
机构：
[1] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10021 USA
[2] Cornell Univ, Grad Sch Med Sci, Sloan Kettering Div, New York, NY 10021 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2001年 / 11卷 / 01期
关键词：
D O I：
10.1016/S0959-437X(00)00161-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Separation of chromosomes during mitosis is monitored by a checkpoint that leads to cell-cycle arrest if the chromosomes are not properly attached to the mitotic spindle. Molecular mechanisms controlling this checkpoint have been identified. In addition, loss of this checkpoint has been shown to result in chromosome missegregation in higher eukaryotes and may contribute to the genomic instability observed in human cancers.
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页码：83 / 90
页数：8
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