Mitotic checkpoints: from yeast to cancer

被引：177

作者：

Wassmann, K

Benezra, R

机构：

[1] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10021 USA

[2] Cornell Univ, Grad Sch Med Sci, Sloan Kettering Div, New York, NY 10021 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2001年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(00)00161-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Separation of chromosomes during mitosis is monitored by a checkpoint that leads to cell-cycle arrest if the chromosomes are not properly attached to the mitotic spindle. Molecular mechanisms controlling this checkpoint have been identified. In addition, loss of this checkpoint has been shown to result in chromosome missegregation in higher eukaryotes and may contribute to the genomic instability observed in human cancers.

引用

收藏

页码：83 / 90

页数：8

相关论文

共 56 条

[31] Kinetochore fiber maturation in PtK1 cells and its implications for the mechanisms of chromosome congression and anaphase onset [J].

McEwen, BF ;

Heagle, AB ;

Cassels, GO ;

Buttle, KF ;

Rieder, CL .

JOURNAL OF CELL BIOLOGY, 1997, 137 (07) :1567-1580

[32]

MICHEL L, IN PRESS NATURE

[33] Expression of Bcl-x(L) and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage [J].

Minn, AJ ;

Boise, LH ;

Thompson, CB .

GENES & DEVELOPMENT, 1996, 10 (20) :2621-2631

[34] Regulation of the APC and the exit from mitosis [J].

Morgan, DO .

NATURE CELL BIOLOGY, 1999, 1 (02) :E47-E53

[35] How cells get the right chromosomes [J].

Nicklas, RB .

SCIENCE, 1997, 275 (5300) :632-637

[36] Isolation and characterization of a pituitary tumor-transforming gene (PTTG) [J].

Pei, L ;

Melmed, S .

MOLECULAR ENDOCRINOLOGY, 1997, 11 (04) :433-441

[37] THE CHECKPOINT DELAYING ANAPHASE IN RESPONSE TO CHROMOSOME MONOORIENTATION IS MEDIATED BY AN INHIBITORY SIGNAL PRODUCED BY UNATTACHED KINETOCHORES [J].

RIEDER, CL ;

COLE, RW ;

KHODJAKOV, A ;

SLUDER, G .

JOURNAL OF CELL BIOLOGY, 1995, 130 (04) :941-948

[38] THE SACCHAROMYCES-CEREVISIAE CHECKPOINT GENE BUB1 ENCODES A NOVEL PROTEIN-KINASE [J].

ROBERTS, BT ;

FARR, KA ;

HOYT, MA .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (12) :8282-8291

[39]

SCONICK DM, 2000, NATURE, V406, P430

[40] Phosphorylation of human MAD1 by the BUB1 kinase in vitro [J].

Seeley, TW ;

Wang, L ;

Zhen, JY .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (02) :589-595

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