Regulation of Primary Response Genes

被引：174

作者：

Fowler, Trent ^{[1
]}

Sen, Ranjan ^{[4
]}

Roy, Ananda L. ^{[1
,2
,3
]}

机构：

[1] Tufts Univ, Sch Med, Sackler Sch Biomed Sci, Dept Pathol, Boston, MA 02111 USA

[2] Tufts Univ, Sch Med, Sackler Sch Biomed Sci, Genet Program, Boston, MA 02111 USA

[3] Tufts Univ, Sch Med, Sackler Sch Biomed Sci, Program Immunol, Boston, MA 02111 USA

[4] NIA, Lab Mol Biol & Immunol, Biomed Res Ctr, Baltimore, MD 21224 USA

来源：

MOLECULAR CELL | 2011年 / 44卷 / 03期

基金：

美国国家卫生研究院;

关键词：

CHROMATIN-REMODELING COMPLEX; TRANSCRIPTION FACTORS; C-FOS; MESSENGER-RNA; HISTONE ACETYLATION; NEURONAL-ACTIVITY; CELL-CYCLE; ACTIVATION; EXPRESSION; KINASE;

D O I：

10.1016/j.molcel.2011.09.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Primary response genes (PRGs) are a set of genes that are induced in response to both cell-extrinsic and cell-intrinsic signals and do not require de novo protein synthesis for their expression. These "first responders" in the waves of transcription of signal-responsive genes play pivotal roles in a wide range of biological responses, including neuronal survival and plasticity, cardiac stress response, innate and adaptive immune responses, glucose metabolism, and oncogeneic transformation. Here we bring together recent advances and our current understanding of the signal-induced transcriptional and epigenetic regulation of PRGs.

引用

页码：348 / 360

页数：13

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