Regulation of Primary Response Genes

被引：174

作者：

Fowler, Trent ^{[1
]}

Sen, Ranjan ^{[4
]}

Roy, Ananda L. ^{[1
,2
,3
]}

机构：

[1] Tufts Univ, Sch Med, Sackler Sch Biomed Sci, Dept Pathol, Boston, MA 02111 USA

[2] Tufts Univ, Sch Med, Sackler Sch Biomed Sci, Genet Program, Boston, MA 02111 USA

[3] Tufts Univ, Sch Med, Sackler Sch Biomed Sci, Program Immunol, Boston, MA 02111 USA

[4] NIA, Lab Mol Biol & Immunol, Biomed Res Ctr, Baltimore, MD 21224 USA

来源：

MOLECULAR CELL | 2011年 / 44卷 / 03期

基金：

美国国家卫生研究院;

关键词：

CHROMATIN-REMODELING COMPLEX; TRANSCRIPTION FACTORS; C-FOS; MESSENGER-RNA; HISTONE ACETYLATION; NEURONAL-ACTIVITY; CELL-CYCLE; ACTIVATION; EXPRESSION; KINASE;

D O I：

10.1016/j.molcel.2011.09.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Primary response genes (PRGs) are a set of genes that are induced in response to both cell-extrinsic and cell-intrinsic signals and do not require de novo protein synthesis for their expression. These "first responders" in the waves of transcription of signal-responsive genes play pivotal roles in a wide range of biological responses, including neuronal survival and plasticity, cardiac stress response, innate and adaptive immune responses, glucose metabolism, and oncogeneic transformation. Here we bring together recent advances and our current understanding of the signal-induced transcriptional and epigenetic regulation of PRGs.

引用

页码：348 / 360

页数：13

共 100 条

[41] The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription [J].

Jang, MK ;

Mochizuki, K ;

Zhou, MS ;

Jeong, HS ;

Brady, JN ;

Ozato, K .

MOLECULAR CELL, 2005, 19 (04) :523-534

[42] Mpk1 MAPK Association with the Paf1 Complex Blocks Sen1-Mediated Premature Transcription Termination [J].

Kim, Ki-Young ;

Levin, David E. .

CELL, 2011, 144 (05) :745-756

[43] Widespread transcription at neuronal activity-regulated enhancers [J].

Kim, Tae-Kyung ;

Hemberg, Martin ;

Gray, Jesse M. ;

Costa, Allen M. ;

Bear, Daniel M. ;

Wu, Jing ;

Harmin, David A. ;

Laptewicz, Mike ;

Barbara-Haley, Kellie ;

Kuersten, Scott ;

Markenscoff-Papadimitriou, Eirene ;

Kuhl, Dietmar ;

Bito, Haruhiko ;

Worley, Paul F. ;

Kreiman, Gabriel ;

Greenberg, Michael E. .

NATURE, 2010, 465 (7295) :182-U65

[44] Functional versatility of transcription factors in the nervous system: the SRF paradigm [J].

Knoell, Bernd ;

Nordheim, Alfred .

TRENDS IN NEUROSCIENCES, 2009, 32 (08) :432-442

[45] Chromatin remodeling complex NURF regulates thymocyte maturation [J].

Landry, Joseph W. ;

Banerjee, Subhadra ;

Taylor, Barbara ;

Aplan, Peter D. ;

Singer, Alfred ;

Wu, Carl .

GENES & DEVELOPMENT, 2011, 25 (03) :275-286

[46] Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in β-cells [J].

Lawrence, Michael C. ;

McGlynn, Kathleen ;

Shao, Chunli ;

Duan, Lingling ;

Naziruddin, Bashoo ;

Levy, Marlon F. ;

Cobb, Melanie H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (36) :13315-13320

[47] Activation and Repression of Cellular Immediate Early Genes by Serum Response Factor Cofactors [J].

Lee, Seung-Min ;

Vasishtha, Mansi ;

Prywes, Ron .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (29) :22036-22049

[48] Promoter proximal pausing and the control of gene expression [J].

Li, Jian ;

Gilmour, David S. .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2011, 21 (02) :231-235

[49] Cotranscriptional coupling of splicing factor recruitment and precursor messenger RNA splicing in mammalian cells [J].

Listerman, Imke ;

Sapra, Aparna K. ;

Neugebauer, Karla M. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (09) :815-822

[50] The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation [J].

Malik, Sohail ;

Roeder, Robert G. .

NATURE REVIEWS GENETICS, 2010, 11 (11) :761-772

← 1 2 3 4 5 6 7 8 9 10 →