Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats

被引：74

作者：

Demogines, Ann ^{[1
]}

Farzan, Michael ^{[2
]}

Sawyer, Sara L. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Mol Genet & Microbiol, Inst Cellular & Mol Biol, Austin, TX 78712 USA

[2] Harvard Univ, Sch Med, Dept Microbiol & Immunol, New England Primate Res Ctr, Southborough, MA 01772 USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 11期

基金：

美国国家卫生研究院;

关键词：

CROSS-SPECIES TRANSMISSION; SARS-LIKE CORONAVIRUS; PRIMATE LENTIVIRUSES; PALM CIVETS; RECEPTOR; EVOLUTION; VIRUS; BINDING; RESERVOIRS; PROTEIN;

D O I：

10.1128/JVI.00311-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In 2002, severe acute respiratory syndrome (SARS)-coronavirus (CoV) appeared as a novel human virus with high similarity to bat coronaviruses. However, while SARS-CoV uses the human angiotensin-converting enzyme 2 (ACE2) receptor for cellular entry, no coronavirus isolated from bats appears to use ACE2. Here we show that signatures of recurrent positive selection in the bat ACE2 gene map almost perfectly to known SARS-CoV interaction surfaces. Our data indicate that ACE2 utilization preceded the emergence of SARS-CoV-like viruses from bats.

引用

页码：6350 / 6353

页数：4

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