Ion channels get flashy

被引：10

作者：

Bayley, H ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

NATURE CHEMICAL BIOLOGY | 2006年 / 2卷 / 01期

关键词：

D O I：

10.1038/nchembio0106-11

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ion channels have essential roles in the nervous system. An engineered ligand-gated channel with a photoactivated switch will be useful for addressing several issues in neuronal signaling.

引用

页码：11 / 13

页数：4

共 11 条

[1]

ASTIER Y, CURR OPIN CHEM

[2] Light-activated ion channels for remote control of neuronal firing [J].

Banghart, M ;

Borges, K ;

Isacoff, E ;

Trauner, D ;

Kramer, RH .

NATURE NEUROSCIENCE, 2004, 7 (12) :1381-1386

[3] A PHOTOGENERATED PORE-FORMING PROTEIN [J].

CHANG, CY ;

NIBLACK, B ;

WALKER, B ;

BAYLEY, H .

CHEMISTRY & BIOLOGY, 1995, 2 (06) :391-400

[4] Cofilin promotes actin polymerization and defines the direction of cell motility [J].

Ghosh, M ;

Song, XY ;

Mouneimne, G ;

Sidani, M ;

Lawrence, DS ;

Condeelis, JS .

SCIENCE, 2004, 304 (5671) :743-746

[5] A light-actuated nanovalve derived from a channel protein [J].

Koçer, A ;

Walko, M ;

Meijberg, W ;

Feringa, BL .

SCIENCE, 2005, 309 (5735) :755-758

[6] Photochemical tools for remote control of ion channels in excitable cells [J].

Kramer, RH ;

Chambers, JJ ;

Trauner, D .

NATURE CHEMICAL BIOLOGY, 2005, 1 (07) :360-365

[7] COVALENTLY BOUND PHOTOISOMERIZABLE AGONIST - COMPARISON WITH REVERSIBLY BOUND AGONISTS AT ELECTROPHORUS ELECTROPLAQUES [J].

LESTER, HA ;

KROUSE, ME ;

NASS, MM ;

WASSERMANN, NH ;

ERLANGER, BF .

JOURNAL OF GENERAL PHYSIOLOGY, 1980, 75 (02) :207-232

[8]

Loudwig S, 2005, DYNAMIC STUDIES IN BIOLOGY: PHOTOTRIGGERS, PHOTOSWITCHES AND CAGED BIOMOLECULES, P253, DOI 10.1002/3527605592.ch5

[9] Flash decaging of tyrosine sidechains in an ion channel [J].

Miller, JC ;

Silverman, SK ;

England, PM ;

Dougherty, DA ;

Lester, HA .

NEURON, 1998, 20 (04) :619-624

[10] Genetically targeted chromophore-assisted light inactivation [J].

Tour, O ;

Meijer, RM ;

Zacharias, DA ;

Adams, SR ;

Tsien, RY .

NATURE BIOTECHNOLOGY, 2003, 21 (12) :1505-1508

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