The synthesis of deuterionucleosides

被引：19

作者：

Földesi, A ^{[1
]}

Trifonova, A ^{[1
]}

Kundu, MK ^{[1
]}

Chattopadhyaya, J ^{[1
]}

机构：

[1] Uppsala Univ, Ctr Biomed, Dept Bioorgan Chem, S-75123 Uppsala, Sweden

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2000年 / 19卷 / 10-12期

关键词：

D O I：

10.1080/15257770008045450

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of deuterionucleosides for site-specific incorporation into oligo-DNA or -RNA is herein reviewed for NMR or biological studies. The review covers the following aspects: (i) deuteration of the aglycone; (ii) single-site chemical deuteration of the sugar residues; (iii) multiple-site chemical deuteration of the sugar residues; (iv) enzymatic synthesis of deuterated nucleosides or nucleotides; and (v) synthesis of labelled nucleosides with multiple isotopes.

引用

页码：1615 / 1656

页数：42

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