miSEA: microRNA set enrichment analysis

被引：18

作者：

Corapcioglu, M. Erdem ^{[1
,2
]}

Ogul, Hasan ^{[1
]}

机构：

[1] Baskent Univ, Dept Comp Engn, TR-06810 Ankara, Turkey

[2] Baskent Univ, Dept Technol & Informat Management, TR-06490 Ankara, Turkey

来源：

BIOSYSTEMS | 2015年 / 134卷

关键词：

microRNA expression profiling; Gene set analysis; Microarray analysis; miRNA-Seq data analysis; MIRNA; TOOL;

D O I：

10.1016/j.biosystems.2015.05.004

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

We introduce a novel web-based tool, miSEA, for evaluating the enrichment of relevant microRNA sets from microarray and miRNA-Seq experiments on paired samples, e.g. control vs. treatment. In addition to a group of previously annotated microRNA sets embedded in the system, this tool enables users to import new microRNA sets obtained from their own research. miSEA allows users to select from a large variety of microRNA grouping categories, such as family classification, disease association, common regulation, and genome coordinates, based on their requirements. miSEA therefore provides a knowledge-driven representation scheme for microRNA experiments. The usability of this platform was discerned with a cancer type-classification task performed on a set of real microRNA expression profiling experiments. The miSEA web server is available at http://www.baskent.edu.tr/similar to hogul/misea (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：37 / 42

页数：6

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