Biological effects of essential oils - A review

被引:5171
作者
Bakkali, F. [1 ,2 ]
Averbeck, S. [1 ]
Averbeck, D. [1 ]
Waomar, M. [2 ]
机构
[1] Ctr Univ, LCR V28 CEA, UMR 2027 CNRS IC, Inst Curie Sect Rech, F-91405 Orsay, France
[2] Univ Abdelmalek Essaadi, Fac Sci, Lab Biol & Sante, Tetouan, Morocco
关键词
essential oil; cytotoxicity; genotoxicity; antigenotoxicity; prooxidant activity;
D O I
10.1016/j.fct.2007.09.106
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Since the middle ages, essential oils have been widely used for bactericidal, virucidal, fungicidal, antiparasitical, insecticidal, medicinal and cosmetic applications, especially nowadays in pharmaceutical, sanitary, cosmetic, agricultural and food industries. Because of the mode of extraction, mostly by distillation from aromatic plants, they contain a variety of volatile molecules such as terpenes and terpenoids, phenol-derived aromatic components and aliphatic components. In vitro physicochemical assays characterise most of them as antioxidants. However, recent work shows that in eukaryotic cells, essential oils can act as prooxidants affecting inner cell membranes and organelles such as mitochondria. Depending on type and concentration, they exhibit cytotoxic effects on living cells but are usually nongenotoxic. In some cases, changes in intracellular redox potential and mitochondrial dysfunction induced by essential oils can be associated with their capacity to exert antigenotoxic effects. These findings suggest that, at least in part, the encountered beneficial effects of essential oils are due to prooxidant effects on the cellular level. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:446 / 475
页数:30
相关论文
共 336 条
[21]   Inhibitory effect of thyme and basil essential oils, carvacrol, thymol, estragol, linalool and p-cymene towards Shigella sonnei and S-flexneri [J].
Bagamboula, CF ;
Uyttendaele, M ;
Debevere, J .
FOOD MICROBIOLOGY, 2004, 21 (01) :33-42
[22]   Antigenotoxic effects of three essential oils in diploid yeast (Saccharomyces cerevisiae) after treatments with UVC radiation, 8-MOP plus UVA and MMS [J].
Bakkali, F. ;
Averbeck, S. ;
Averbeck, D. ;
Zhiri, A. ;
Baudoux, D. ;
Idaomar, M. .
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2006, 606 (1-2) :27-38
[23]   Cytotoxicity and gene induction by some essential oils in the yeast Saccharomyces cerevisiae [J].
Bakkali, F ;
Averbeck, S ;
Averbeck, D ;
Zhiri, A ;
Idaomar, A .
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2005, 585 (1-2) :1-13
[24]   Phenolic compounds in red oak and sugar maple leaves have prooxidant activities in the midgut fluids of Malacosoma disstria and Orgyia leucostigma caterpillars [J].
Barbehenn, R ;
Cheek, S ;
Gasperut, A ;
Lister, E ;
Maben, R .
JOURNAL OF CHEMICAL ECOLOGY, 2005, 31 (05) :969-988
[25]   The essential oil constituents and antimicrobial activity of Anthemis aciphylla Boiss. var. discoidea Boiss. [J].
Baser, KHC ;
Demirci, B ;
Iscan, G ;
Hashimoto, T ;
Demirci, F ;
Noma, Y ;
Asakawa, Y .
CHEMICAL & PHARMACEUTICAL BULLETIN, 2006, 54 (02) :222-225
[26]   Antibacterial and antioxidant activities in Sideritis italica (Miller) Greuter et Burdet essential oils [J].
Basile, Adriana ;
Senatore, Felice ;
Gargano, Rosalba ;
Sorbo, Sergio ;
Del Pezzo, Marisa ;
Lavitola, Alfredo ;
Ritieni, Alberto ;
Bruno, Maurizio ;
Spatuzzi, Daniela ;
Rigano, Daniela ;
Vuotto, Maria Luisa .
JOURNAL OF ETHNOPHARMACOLOGY, 2006, 107 (02) :240-248
[27]   Inhibitory effects of some spice essential oils on Aspergillus ochraceus NRRL 3174 growth and ochratoxin A production [J].
Basílico, MZ ;
Basílico, JC .
LETTERS IN APPLIED MICROBIOLOGY, 1999, 29 (04) :238-241
[28]   Chemical characterisation of the different types of volatile oil constituents by various solute retention ratios with the use of conventional and novel commercial gas chromatographic stationary phases [J].
Betts, TJ .
JOURNAL OF CHROMATOGRAPHY A, 2001, 936 (1-2) :33-46
[29]  
Bhatnagar Mala, 1993, Journal of Entomological Research (New Delhi), V17, P21
[30]  
Bijur GN, 1997, ENVIRON MOL MUTAGEN, V30, P339, DOI 10.1002/(SICI)1098-2280(1997)30:3&lt